Table 2.
Cerebellum | Prefrontal cortex | |||
---|---|---|---|---|
SP4 (protein) | SP1 (protein) | SP4 (protein) | SP4 (mRNA) | |
Age (years) | ||||
Spearman’s r | 0.2536 | −0.144 | −0.420 | −0.252 |
p-value | 0.2807 | 0.546 | 0.065 | 0.284 |
Gender (male/female) | ||||
Mann-Whitney’s p-value | 0.6707 | 0.3211 | 0.6707 | 0.2376 |
PMD (hours) | ||||
Spearman’s r | −0.281 | −0.432 | 0.618 | 0.073 |
p-value | 0.230 | 0.057 | 0.004 | 0.761 |
Toxicology | ||||
Kruskal-Wallis p-value | 0.9583 | 0.8581 | 0.2947 | 0.8562 |
SP4 and SP1 protein levels in the cerebellum and prefrontal cortex were compared to subjects’ age, gender, postmortem delay (PMD), and toxicology in order to detect if any of these variables was influencing the data. RNA integrity number was also analyzed as a possible variable influencing SP4 mRNA in the prefrontal cortex (r = 0.597, p = 0.005). Correlation among quantitative variables was analyzed by r of Spearman. Qualitative variables were analyzed by Mann-Whitney’s test for two groups and Kruskal-Wallis for more than three groups.