Table I.
Characteristics of all TGCT casesa: all cases, seminoma cases, mixed germ cell tumor cases and nonseminoma cases
| Characteristic | All casesa (N = 273), N (%) | Seminoma (N = 140), N (%) | Mixed germ cell tumors (N = 53), N (%) | Pure nonseminoma (N = 68), N (%) |
| Age at diagnosisb | ||||
| ≤25 | 48 (17.6) | 9 (6.4) | 9 (17.0) | 28 (41.2) |
| 26–30 | 52 (19.1) | 18 (12.9) | 14 (26.4) | 16 (23.5) |
| 31–35 | 67 (24.5) | 39 (27.9) | 13 (24.5) | 13 (19.1) |
| 36–40 | 57 (20.9) | 35 (25.0) | 13 (24.5) | 7 (10.3) |
| >40 | 48 (17.6) | 39 (27.5) | 4 (7.6) | 4 (5.9) |
| Unknown | 1 (0.4) | |||
| Diagnosis date | ||||
| 1974–1984 | 24 (8.8) | 11 (7.9) | — | 8 (11.8) |
| 1985–1989 | 35 (12.8) | 17 (12.1) | 3 (5.6) | 14 (20.6) |
| 1990–1994 | 60 (22.0) | 27 (19.3) | 14 (26.4) | 19 (27.9) |
| 1995–2000 | 85 (31.1) | 51 (36.4) | 18 (34.0) | 12 (17.6) |
| 2000–2006 | 68 (24.9) | 34 (24.3) | 18 (34.0) | 15 (22.1) |
| Unknown | 1 (0.4) | |||
| Race/ethnicity | ||||
| Non-Hispanic white | 244 (89.1) | 125 (89.3) | 48 (90.6) | 62 (88.2) |
| Hispanic white | 16 (6.2) | 8 (5.7) | 3 (5.7) | 5 (7.4) |
| African-American | 4 (1.5) | 1 (0.7) | 1 (1.9) | 2 (2.9) |
| Asian | 5 (1.8) | 3 (2.1) | 1 (1.9) | 1 (1.5) |
| Unknown | 4 (1.5) | 3 (2.1) | ||
| TGCT laterality | ||||
| Unilateral | 244 (89.4) | 126 (90.0) | 41 (77.4) | 65 (95.6) |
| Bilateral | 29 (10.6) | 14 (10.0) | 12 (22.6) | 3 (4.4) |
| Personal history of cryptorchidism | ||||
| None | 219 (80.2) | 112 (80.0) | 44 (83.0) | 53 (77.9) |
| Unilateral | 40 (14.7) | 19 (13.6) | 6 (11.3) | 13 (19.1) |
| Bilateral | 6 (2.2) | 4 (2.9) | 2 (3.8) | 0b |
| Laterality unknown | 8 (2.9) | 5 (3.6) | 1 (1.9) | 2 (3.0) |
| Family history | ||||
| None | 98 (35.9) | 40 (28.6) | 26 (49.0) | 31 (45.6) |
| TGCT only | 76 (27.8) | 45 (32.1) | 11 (20.8) | 12 (17.7) |
| CO onlyc | 80 (29.3) | 47 (33.6) | 14 (26.4) | 19 (27.9) |
| TGCT and COc | 19 (7.0) | 8 (5.7) | 2 (3.8) | 6 (8.8) |
| Histologyd | ||||
| Seminoma | 140 (51.3) | 140 (100) | — | — |
| Pure seminoma | 134 (95.7) | 134 (95.7) | — | — |
| Anaplastic seminoma | 4 (2.9) | 4 (2.9) | — | — |
| Spermatocytic seminoma | 2 (1.4) | 2 (1.4) | — | — |
| Mixed germ cell tumor | 53 (19.4) | — | 53 (100) | — |
| Pure Nonseminoma | 68 (24.9) | — | — | 68 (100) |
| Embryonal carcinoma | 36 (13.2) | — | — | 36 (52.9) |
| Teratocarcinoma | 18 (26.5) | — | — | 18 (26.5) |
| Teratoma | 6 (8.8) | — | — | 6 (8.8) |
| Yolk sac | 3 (1.1) | — | — | 3 (4.4) |
| Choriocarcinoma | 5 (1.8) | — | — | 5 (7.4) |
| Unknown | 12 (4.4) |
a
Histology is unknown for 12 TGCT cases.
b
Age at first diagnosis is used for cases with two primary TGCTs (bilateral cases).
c
CO, cryptorchidism.
d
Histology details on 29 bilateral cases (first TGCT/second TGCT = number of cases): seminoma: seminoma/seminoma = 8, seminoma/spermatocytic seminoma = 1, seminoma/unknown = 5; Mixed germ cell tumor: mixed GCT/mixed GCT = 1, seminoma/mixed GCT = 5, seminoma/teratoma = 4, mixed GCT/embryonal = 1, mixed GCT/unknown = 1; pure nonseminoma: teratoma/teratoma = 1, teratoma/unknown = 2.