Table III.

ORs and 95% CIs for the association of AR CAG repeat length and risk of TGCT among all cases and subgroups defined by histology, comparing case and control alleles

	All TGCT case/control	Seminomaacase/control	Mixed GCTacase/control	Nonseminomaa case/control
A. All races/ethnicities
No. CAG repeats	(N = 546)	(N = 280)	(N = 106)	(N = 136)
≤19	83/73	48/31	12/13	17/25
≥20	190/200	92/109	41/40	51/43
20–21	80/73	45/36	14/13	19/19
22–23	56/61	24/37	13/12	17/11
≥24	54/66	23/36	14/15	15/13
OR (95% CI)b
≤19	1.0 (ref)	1.0 (ref)	1.0 (ref)	1.0 (ref)
≥20	0.84 (0.58–1.21)	0.54 (0.31–0.93)	1.10 (0.47–2.59)	1.80 (0.83–3.90)
20–21	0.96 (0.61–1.49)	0.82 (0.43–1.58)	1.13 (0.40–3.20)	1.53 (0.61–3.87)
22–23	0.81 (0.50–1.29)	0.39 (0.19–0.83)	1.13 (0.40–3.20)	2.11 (0.83–5.34)
≥24	0.72 (0.44–1.17)	0.42 (0.20–0.86)	1.01 (0.35–2.94)	1.79 (0.66–4.85)
	Ptrend = 0.13	Ptrend = 0.0030	Ptrend = 0.98	Ptrend = 0.17
			Pcheterogeneity = 0.17	Pcheterogeneity = 0.012
Non-Hispanic whites
No. CAG repeats	(N = 488)	(N = 250)	(N = 96)	(N=120)
≤19	75/63	44/24	11/13	14/22
≥20	169/181	81/101	37/35	46/38
20–21	73/66	40/33	14/11	17/18
22–23	49/54	22/33	11/11	15/9
≥24	47/61	19/35	12/13	14/11
OR (95% CI)b
≤19	1.0 (ref)	1.0 (ref)	1.0 (ref)	1.0 (ref)
20	0.79 (0.53–1.17)	0.43 (0.23–0.79)	1.22 (0.51–2.95)	1.89 (0.84–4.24)
20–21	0.92 (0.57–1.49)	0.65 (0.32–1.34)	1.47 (0.49–4.44)	1.49 (0.56–3.95)
22–23	0.77 (0.47–1.26)	0.36 (0.17–0.78)	1.10 (0.38–3.26)	2.30 (0.85–6.22)
≥24	0.65 (0.39–1.09)	0.29 (0.13–0.65)	1.11 (0.37–3.35)	1.97 (0.70–5.53)
	Ptrend = 0.10	Ptrend < 0.001	Ptrend = 0.98	Ptrend = 0.12
			Pcheterogeneity = 0.055	Pcheterogeneity = 0.0040

^aHistologic subgroups include all TGCT cases (unilateral and bilateral) without cryptorchidism.

^bLogistic regression [comparing case (transmitted) allele to control (untransmitted) allele].

^cP value from heterogeneity test comparing the trend in seminoma cases with the trend in mixed germ cell tumor or nonseminoma cases.