Table IV.
Case–case analyses displaying ORs and 95% CIs for the association of AR CAG repeat length with TGCT histology comparing seminoma cases with mixed germ cell tumor and nonseminoma cases
| Seminoma cases/mixed GCT casesa | OR (95% CI)b | Seminoma cases/nonseminoma casesa | OR (95% CI)b | |
| A. All races/ethnicities | ||||
| No. CAG repeats | (N = 188) | (N = 203) | ||
| ≤19 | 46/12 | 1.0 (ref) | 46/17 | 1.0 (ref) |
| ≥20 | 90/40 | 0.55 (0.26–1.17) | 90/50 | 0.56 (0.27–1.17) |
| 20–21 | 45/14 | 0.81 (0.33–1.98) | 45/18 | 1.00 (0.41–2.45) |
| 22–23 | 24/13 | 0.47 (0.18–1.24) | 24/16 | 0.36 (0.14–0.96) |
| ≥24 | 21/13 | 0.36 (0.13–0.95) | 21/16 | 0.34 (0.13–0.92) |
| Ptrend = 0.021 | Ptrend = 0.0096 | |||
| B. Non-Hispanic whites | ||||
| No. CAG repeats | (N = 171) | (N = 183) | ||
| ≤19 | 43/11 | 1.0 (ref) | 43/14 | 1.0 (ref) |
| ≥20 | 81/36 | 0.52 (0.24–1.16) | 81/45 | 0.47 (0.22–1.02) |
| 20–21 | 40/14 | 0.69 (0.28–1.77) | 40/16 | 0.87 (0.34–2.22) |
| 22–23 | 22/11 | 0.46 (0.16–1.28) | 22/14 | 0.28 (0.10–0.79) |
| ≥24 | 19/11 | 0.36 (0.13–1.03) | 19/15 | 0.27 (0.10–0.78) |
| Ptrend = 0.036 | Ptrend = 0.0039 |
a
Includes unilateral and bilateral TGCT cases with histology, race, ethnicity and age at diagnosis available.
b
Adjusted for age at diagnosis (≤25, 26–30, 31–35, 36–40, >40).