Table 3.
Association of Breastfeeding With Morbidity: Adjusted Rate Ratios—Multivariable Poisson Regression Models, PEPI-Malawi Study, 2004–09
| Illness/admission |
Malnutrition |
|||
| RR 95% CI | P Value | RR 95% CI | P Value | |
| 6–9 Months | ||||
| NBF vs BF | 1.70 1.37–2.11 | <.0001 | 1.37 1.05–1.79 | .02 |
| Infant extended ARV prophylaxis (Yes vs No) | 1.04 0.86–1.24 | .70 | 0.81 0.64–1.03 | .08 |
| Maternal HIV stage 3 or 4 vs stage 1 or 2 | 1.18 0.98–1.42 | .08 | 1.35 1.06–1.71 | .02 |
| Infant CTX prophylaxis (Yes vs No) | 0.56 0.47–0.66 | <.0001 | 0.72 0.58–0.90 | <.005 |
| 9–12 months | ||||
| NBF vs BF | 1.66 1.28–2.14 | .0001 | 1.34 0.97–1.83 | .07 |
| Infant extended ARV prophylaxis (Yes vs No) | 1.04 0.86–1.25 | .69 | 0.80 0.63–1.01 | .06 |
| Maternal HIV stage 3 or 4 vs stage 1 or 2 | 1.13 0.94–1.35 | .21 | 1.09 0.85–1.39 | .51 |
| Infant CTX prophylaxis (Yes vs No) | 0.65 0.55–0.77 | <.0001 | 0.71 0.56–0.89 | .003 |
| 12–15 months | ||||
| NBF vs BF | 1.75 1.26–2.43 | .0008 | 1.91 1.27–2.89 | .002 |
| Infant extended ARV prophylaxis (Yes vs No) | 0.86 0.71–1.03 | .11 | 0.89 0.70–1.13 | .33 |
| Maternal HIV stage 3 or 4 vs stage 1 or 2 | 1.27 1.06–1.53 | <.01 | 1.06 0.83–1.35 | .65 |
| Infant CTX prophylaxis (Yes vs No) | 0.77 0.63–0.92 | <.005 | 1.11 0.89–1.40 | .34 |
NOTE. Excluding infant prophylaxis from this analysis did not change the results; kept in the model to maintain original study design. ARV, Antiretroviral; BF, Breastfeeding; CTX, Cotrimoxazole; NBF, Not breastfeeding; RR, Rate ratio.