TABLE 4.
Arterial blood angiotensin I, angiotensin II, bradykinin, and bradykinin 1–5 levels and ratios of angiotensin II/I and bradykinin 1–5 to bradykinin before treatment (0 min) and during the experimental period (65–485 min)
Mean ± S.E.M.; n = 9 per group.
| 0 | 65 | 125 | 185 | 245 | 305 | 365 | 425 | 485 | |
|---|---|---|---|---|---|---|---|---|---|
| Arterial blood angiotensin I (pg/ml) | |||||||||
| Inhalation | 269 ± 89 | 94 ± 26 | 75 ± 13 | 66 ± 9 | 82 ± 15 | 81 ± 14 | 84 ± 9 | 100 ± 23 | 100 ± 14 |
| Intravenous infusion | 416 ± 120 | 193 ± 58 | 133 ± 37 | 120 ± 47 | 123 ± 41 | 182 ± 76 | 133 ± 36 | 142 ± 34 | 143 ± 37 |
| Arterial blood angiotensin II (pg/ml) | |||||||||
| Inhalation | 38 ± 14 | 9 ± 2 | 9 ± 2 | 8 ± 1 | 9 ± 3 | 9 ± 1 | 10 ± 2 | 9 ± 1 | 9 ± 1 |
| Intravenous infusion | 72 ± 24 | 14 ± 3 | 10 ± 2 | 10 ± 2 | 8 ± 2 | 9 ± 2 | 9 ± 2 | 8 ± 1 | 8 ± 2 |
| Arterial blood bradykinin (fmol/ml) | |||||||||
| Inhalation | 11 ± 2 | 10 ± 2 | 10 ± 1 | 11 ± 2 | 12 ± 2 | 11 ± 2 | 9 ± 1 | 9 ± 2 | 10 ± 2 |
| Intravenous infusion | 7 ± 1 | 6 ± 1 | 7 ± 2 | 7 ± 1 | 7 ± 1 | 8 ± 1 | 8 ± 1 | 9 ± 1 | 9 ± 1 |
| Arterial blood bradykinin 1–5 (fmol/ml) | |||||||||
| Inhalation | 13 ± 2 | 12 ± 2 | 14 ± 3 | 15 ± 4 | 17 ± 4 | 16 ± 4 | 17 ± 3 | 17 ± 3 | 16 ± 4 |
| Intravenous infusion | 14 ± 5 | 9 ± 3 | 8 ± 3 | 10 ± 3 | 11 ± 3 | 14 ± 3 | 14 ± 3 | 17 ± 3 | 21 ± 3 |
| Angiotensin II/I ratio | |||||||||
| Inhalation | 0.2 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 |
| Intravenous infusion | 0.2 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 |
| Bradykinin 1–5/bradykinin ratio | |||||||||
| Inhalation | 1.8 ± 0.6 | 1.6 ± 0.4 | 1.7 ± 0.4 | 1.7 ± 0.5 | 1.8 ± 0.5 | 1.9 ± 0.5 | 2.0 ± 0.4 | 3.0 ± 1.1 | 2.1 ± 0.5 |
| Intravenous infusion | 2.2 ± 0.8 | 1.4 ± 0.4 | 1.7 ± 0.7 | 1.4 ± 0.3 | 1.6 ± 0.4 | 1.7 ± 0.5 | 2.0 ± 0.5 | 2.3 ± 0.6 | 2.7 ± 0.7 |