Skip to main content
. 2011 Oct 26;6(10):e26776. doi: 10.1371/journal.pone.0026776

Figure 5. Drug-induced increase in netrin-1 production is also mediated by ERK MAPK pathway.

Figure 5

A. 50 uM cisplatin was added to confluent culture with/without U0126. Six hours after addition supernatant was harvested. Netrin-1 was quantified by ELISA. Cisplatin significantly increased netrin-1 production, which was suppressed in the presence of U0126. *, p<0.001 vs. control. #, p<0.001 vs. cisplatin. n = 4. B. Lipopolysaccharide (µg/ml) was added to confluent culture with/without U0126. Two hours after addition, supernatant was harvested. Netrin-1 was quantified by ELISA. Lipopolysaccharide significantly increased netrin-1 production, which was suppressed in the presence of U0126. *, p<0.001 vs. control. #, p<0.001 vs. LPS. n = 4.