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. Author manuscript; available in PMC: 2011 Oct 27.
Published in final edited form as: Cancer Res. 2010 May 1;70(9):3687–3696. doi: 10.1158/0008-5472.CAN-09-3931

Figure 4.

Figure 4

Effect of sustained siRNA delivery on angiogenesis and cell proliferation. Tumors from animals with the SKOV3ip1 ovarian tumor were examined for microvessel density (CD31) and cell proliferation (Ki67). Representative sections from each treatment group are shown (final magnification, ×100 for CD31 and ×400 for Ki67), with mean number of vessels per field or mean % of proliferative cells, summarized in the graph at the bottom. Five different fields per slides, at least three individual tumors per treatment group were examined. Both microvessel density (MVD; A and C) and cell proliferation (B and D) were significantly reduced in tumor when treated with repeated administration of EphA2-siRNA-DOPC and a single administration of the S1MP-EphA2-siRNA-DOPC. (overall ANOVA: **, P < 0.001).