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. Author manuscript; available in PMC: 2011 Oct 27.
Published in final edited form as: Cancer Res. 2010 May 1;70(9):3687–3696. doi: 10.1158/0008-5472.CAN-09-3931

Figure 5.

Figure 5

Biodistribution of S1MP. A, silicon content analysis of organs isolated from mice (n = 6) following i.v. injection of S1MP-EphA2-siRNA-DOPC. The major organs including heart, lung, liver, kidney, and spleen were harvested 4 h after the i.v. injection. Silicon amounts were measured by inductively coupled plasma atomic emission spectroscopy and expressed as % of injected dose per organ (% ID). n.d., not detectable. B, H&E staining of the liver and spleen sections. The liver and spleen were harvested from the mice injected with S1MP-EphA2-siRNA-DOPC and fixed with formalin. Five-micrometer paraffin sections were stained with H&E to identify the localization of S1MP in the organs. Arrows, S1MP (final magnification, ×1,000). C, transmission electron microscopic images of S1MP in the liver and spleen. S1MP remained within the sinusoidal space in the liver (red arrow). K, Kupffer cell; R, RBC; SS, sinusoidal space; H, hepatocyte; M, macrophage (original magnification, ×10,000).