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. 2011 Sep 7;14(3):415–427. doi: 10.1016/j.cmet.2011.06.017

Figure 7.

Figure 7

Synchronization of Redox and Energy Metabolism by Pyruvate Kinase

Low PYK activity increases respiration. At the same time, the PYK substrate PEP accumulates. This stimulates the PPP by feedback inhibition of TPI, which in turn prevents ROS accumulation during respiration.