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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Trends Cell Biol. 2011 Jul 23;21(10):604–614. doi: 10.1016/j.tcb.2011.06.007

Figure 2. Localization and activities of XMAP215/Dis and CLASP proteins.

Figure 2

A) Drosophila Msps (XMAP215/Dis1) on spindle MTs and poles.

B) Drosophila Msps on interphase MT plus ends (Msps, red, arrowhead; tubulin, green)

C) Human CLASP1 on anaphase spindle, at spindle midzone MTs and poles (arrows)(CLASP1, green; MT, red; DNA blue).

D) Human CLASP1 at kinetochore on a metaphase chromosome (CLASP green; DNA, blue; ACA centromere marker, red).

E) Human CLASP2 staining at interphase MT plus ends near plasma membrane (CLASP, red; MT, green).

F) Fission yeast CLASP Cls1p in clusters on interphase MT bundles near nuclear envelope (Cls1p, green; MT, red).

G) Human CLASP1 on the lattice of interphase MTs near the leading edge of the cell (arrowhead).

H) Schematic showing dynamic behavior of pure MTs (grey lines)

I) XMAP215 (green) at the MT plus end accelerates MT assembly and leads to formation of long MTs.

J) S. pombe CLASP, Cls1p (red) binds to the MT lattice and promotes local MT rescue, preventing MTs from shrinking completely.

Images in A–G are reproduced with permission from [40] [24, 48, 53, 61, 63].