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. Author manuscript; available in PMC: 2013 Jan 30.
Published in final edited form as: Mol Cell Endocrinol. 2011 Jun 1;348(2):430–439. doi: 10.1016/j.mce.2011.04.021

Figure 1. SRC-mediated coactivation of NRs.

Figure 1

SRC proteins are recruited to hormone bound NRs and bind through their LXXLL motifs, of which they have three. SRCs then recruit multiple secondary coactivator complexes that bind to their three activation domains (ADs). Three examples are shown: histone acetyltransferase, p300/CBP; histone methyltransferases, PRMT1 and CARM1; and chromatin remodeling complex, SWI/SNF. These secondary coactivators modify the chromatin and bridge the NR complex with the general transcription machinery to elicit transcriptional activation. SRCs (steroid receptor coactivators); bHLH/PAS (basic helix-loop-helix/Per-Arnt-Sim); S/T (serine/threonine –rich region); NR (nuclear receptor); Ac (acetylation); Me (methylation); HRE (hormone response element); L (LXXLL motifs).