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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Gastroenterology. 2011 Jul 27;141(5):1915–1926.e14. doi: 10.1053/j.gastro.2011.07.033

Figure 3. DC depletion in acute pancreatitis results in pancreatic necrosis.

Figure 3

(A-C) Mice were challenged for two days with caerulein after DC depletion or mock depletion. (A) Pancreata were analyzed using H&E. (B) The percentage of non-viable acinar cells was determined by examining 10 HPF per mouse (mean 5 mice per group). (C) Cohorts of mice (4-5 per group) were not sacrificed but instead analyzed for survival according to the Kaplan-Meier method. (D) Diffuse acinar cell death was specific to DC depletion and not mouse strain or DPT treatment. Notably, treatment of CD11b.DTR mice with caerulein and DPT to deplete macrophages did not result in exacerbated injury. Mouse strain is indicated in parentheses preceded by treatment (***p<0.001).