Figure 6. Effects of DC depletion in pancreatitis.
Mice were challenged for two days with caerulein after DC depletion or mock depletion. Serum levels of (A) amylase and (B) TNF-α, IL-6, and MCP-1 were measured at 48 hours. (C) The fraction of pancreatic area occupied by islets and (D) serum levels of glucose were also measured. (E, F) RNA was harvested from whole pancreata and analyzed for expression of (E) IL6, MIP1A, and (F) EGR1. Assays were performed in triplicate and repeated three times (*p<0.05; ***p<0.001).