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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Gastroenterology. 2011 Jul 27;141(5):1915–1926.e14. doi: 10.1053/j.gastro.2011.07.033

Figure 7. Additional cellular depletion or cytokine blockade does not mitigate the effects of DC depletion on pancreas viability.

Figure 7

Pancreata were harvested from C-DC mice and controls and (A) the number of intra-pancreatic CD45+ leukocytes and (B) the number and fraction of pancreas infiltrating neutrophils were examined by both immunohistochemistry and flow cytometry. (C) The time course of neutrophil recruitment was determined by immunohistochemistry. Mice were sacrificed either one hour after the final dose of caerulein or after a 12 hour delay. (D) Acinar death in C-DC mice was studied in mice concurrently depleted of neutrophils, CD4+ T cells, mice with blockaded NF-κB signaling, or treated with neutralizing antibodies targeting IL-6, MIP-1α, or TNF-α (mean 4 mice/group; *p<0.05; **p<0.01; ***p<0.001).