Table 1.

Dosing in patients with diminished renal function

Renal status	Initial dose	Subsequent dose
CLCR ≥ 50 mL/min	500 mg	500 mg q24h
CLCR 20–49 mL/min	500 mg	250 mg q24h
CLCR 10–19 mL/min	500 mg	250 mg q48h
Hemodialysis	500 mg	250 mg q48h
CAPD	500 mg	250 mg q48h
CLCR ≥ 50 mL/min	750 mg	750 mg q24h
CLCR 20–49 mL/min	750 mg	750 mg q48h
CLCR 10–19 mL/min	750 mg	500 mg q48h
Hemodialysis	750 mg	500 mg q48h
CAPD	750 mg	500 mg q48h

Abbreviations: CL_CR, creatinine clearance; CAPD, chronic ambulatory peritoneal dialysis; q, every.