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. 2011 Sep 13;7:529. doi: 10.1038/msb.2011.62

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Copyright © 2011, EMBO and Macmillan Publishers Limited

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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Pre-mRNA production overshoot is a general operational strategy in mammalian transcriptional networks. The plots in (A–F) show qPCR measurements of pre-mRNA (red) and mature mRNA (blue) expression profiles for selected genes exhibiting production overshoot. Dots represent averages of technical triplicate measurements and solid lines represent best fit (see Supplementary information). Production and degradation profiles were inferred from these measurements as described in Materials and methods, and their time-dependent profiles are indicated by green and gold curves, respectively. (A–C) Production overshoot in retinoic acid (RA)-stimulated human embryonic stem cells. (D–F) Production overshoot in lipopolysaccharide (LPS)-stimulated primary murine dendritic cells.