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. 2011 Sep 13;7:529. doi: 10.1038/msb.2011.62

Figure 7.

Figure 7

Pre-mRNA production overshoot is a general operational strategy in mammalian transcriptional networks. The plots in (AF) show qPCR measurements of pre-mRNA (red) and mature mRNA (blue) expression profiles for selected genes exhibiting production overshoot. Dots represent averages of technical triplicate measurements and solid lines represent best fit (see Supplementary information). Production and degradation profiles were inferred from these measurements as described in Materials and methods, and their time-dependent profiles are indicated by green and gold curves, respectively. (A–C) Production overshoot in retinoic acid (RA)-stimulated human embryonic stem cells. (D–F) Production overshoot in lipopolysaccharide (LPS)-stimulated primary murine dendritic cells.

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