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. 2010 Jan 28;2(2):205–214. doi: 10.3390/toxins2020205

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© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Domain architecture of the C-terminal part of PMT. The crystal structure of the C-terminal part of PMT (amino acids 575-1285) revealed 3 domains C1, C2 and C3. The C1 domain (magenta) has similarities with a domain of Clostridium difficile toxin B and targets the toxin to the inner part of the plasma membrane. The function of the C2 domain (green) is unknown. The C3 domain provides a catalytic cleft (arrow) and harbors the biological activity of the toxin. This image was generated using PyMol and PDB data file 2EBF.