| Phospholipases-D (SicTox family members, such as LiRecDTs) |
30–35 |
Several isoforms with variant features such as:
- Dermonecrosis [12,13,16,32,33,34,35,36,37,38] - Lipids hydrolysis [33,39,40,41,42] - Hemolysis [38,43,44,45] - In vitro platelet aggregation [34,36,37] - Infiltration of inflammatory cells [35,36,37,42] - Edema [34,38] - Renal disturbances [35,46] - Lethality [34,38,46,47] - In vitro cytotoxicity [35,42,46] - Cytokine activation [41,48,49,50]
|
335 |
| Insecticidal peptides |
5–8 |
- LiTx family members [23,27] and Magi 3-related peptides [23,27,51] - LiTx: Lethal to S. frugiperda (flaccid paralysis) [23] - LiTx3: appears to act upon Na+ channels [23] |
8 |
| Metalloproteases |
28–35 |
- Astacin-like Metalloprotease (LALPs) [29,52] - Present in the venom of different species of Loxosceles genus [12,13,27,51,53] - Activity upon gelatin, fibronectin, fibrinogen and entactin [18,52,53,54] |
4 |
| Hyaluronidases |
41–43 |
- Classified as endo-beta-N-acetyl-d-hexosaminidases hydrolases [14] - Activity upon hyaluronic acid and chondroitin sulphate [13,14] - Present in the venom of different species of Loxosceles genus [12,13,14,24,27,51,55] |
- |
| Serine-proteases |
85–95 |
- Gelatinolytic activity [19] - Activated in vitro by trypsin [19] - Present in the venom of L. intermedia and L. laeta [27,51] |
- |
| Serine/Cysteine protease inhibitors |
N.D. |
- Belongs to Serpin superfamily [27] - Identified in Loxosceles spp. transcriptomes and proteome [24,27,51] - May be related to coagulation processes, fibrinolysis and inflammation [51] |
- |
| TCTP (translationally controlled tumour protein) |
~46 |
- Identified in Loxosceles spp. transcriptomes [27,51] - Putative functions: Histamine releasing factor in extracellular environment; several intracellular roles such as embryonic development, cell proliferation, stabilization of microtubules [56] |
- |
| Lectin-like |
N.D. |
- Putative features: carbohydrate-binding molecules; involved in extracellular matrix organization, endocytosis, complement activation, etc. [51] |
- |
| Alkaline-phosphatase |
N.D. |
- Degrades the synthetic substrate p-nitrophenyl phosphate[10] |
- |
| ATPase |
N.D |
- ATP hydrolysis [10] |
- |
