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. 2011 Aug 25;3(9):1065–1088. doi: 10.3390/toxins3091065

Figure 2.

Figure 2

Biological evaluation of HPMA-based heterobifunctional inhibitors of Stx1. Panel A: inhibition of Stx1 binding to Gb3 analog-coated microtiter plates; Panel B: inhibition of intoxication of Vero cells with Stx1 (LD100 25 ng/mL); Panel C: protection of from intoxication with Stx1 at LD100. Survival plot demonstrating the efficacy of HPMA-n2 compared with the original PolyBAIT in preventing Stx1-mediated lethality in human SAP-transgenic mice. Mice received a single anterior dorsal injection of a lethal dose of Stx1 (LD100 20 ng/g of body weight) that was premixed with a heterobifunctional inhibitor.