Table 2.
Activities of PolyBAITs.
| Polymer | Pendant Ligand Type | Linker | Payload, % | IC50, μg/mL | IC50, μM a |
|---|---|---|---|---|---|
| HPMA-n0 b | Fused | Short | 5 | 3.7 | 1.07 |
| HPMA-n1 | Fused | Long | 5 | 0.98 | 0.27 |
| HPMA-n2 | Fused | Extra long | 5 | 0.45 | 0.12 |
| HPMA-16/5-A c | Fused | Long | 5 | 1.2 | 0.32 |
| HPMA-44/5-A | Fused | Long | 5 | 0.22 | 0.06 |
| HPMA-35/10-A | Fused | Long | 10 | 0.25 | 0.11 |
| HPMA-20/15-A | Fused | Long | 15 | 0.24 | 0.13 |
| HPMA-37/15-A | Fused | Long | 15 | 0.19 | 0.106 |
| HPMA-44/5-B | Separate | Short | 5 | 0.35 | 0.095 |
| HPMA-35/10-B | Separate | Short | 10 | 0.29 | 0.13 |
| HPMA-44/5-C | Separate | Long | 5 | 0.27 | 0.07 |
| HPMA-35/10-C | Separate | Long | 10 | 0.28 | 0.12 |
| PAA-27/5-A | Fused | Long | 5 | 0.019 | 0.008 |
| PAA-72/5-A | Fused | Long | 5 | 0.046 | 0.019 |
a based on pendant ligand; b this and the following polymers are named according to the principle monomer followed by the number of extension linkers holding pendant ligand; c this and the following polymers are named according to the principle monomer; indices show molecular weight in kDa, % substitution with pendant ligands and type of conjugated unimeric ligand.