Table 2.
Selected Genes Differentially Expressed in Lung Mesenchymal Stromal Cells Relative to Cord Blood Mesenchymal Stromal Cells
| Symbol | Differential score P value | Fold increase | Definition |
|---|---|---|---|
| Development | |||
| HOXB5 | 0.04632 | 56.85 | Homeobox B5 |
| HOXA5 | 0.03145 | 36.98 | Homeobox A5 |
| FOXF1 | 0.00008 | 19.59 | Forkhead box F1 |
| LBH | 0.00035 | 10.40 | Limb bud and heart development homolog (mouse) |
| HOXB7 | 0.00522 | 9.77 | Homeobox B7 |
| WNT5A | 0.02439 | 6.51 | Wingless-type MMTV integration site family, member 5A |
| HOXB6 | 0.0352 | 5.84 | Homeobox B6 |
| HOXB3 | 0.00387 | 3.58 | Homeobox B3 |
| TBX3 | 0.03147 | 3.54 | T-box 3, transcript variant 1 |
| HOXB4 | 0.00313 | 3.22 | Homeobox B4 |
| HOXA2 | 0.0344 | 3.14 | Homeobox A2 |
| RUNX1 | 0 | 2.53 | Runt-related transcription factor 1, transcript variant 1 |
| HOXA4 | 0.00049 | 1.95 | Homeobox A4 |
| GLI2 | 0.01815 | 1.87 | GLI-Kruppel family member GLI2 |
| NOTCH1 | 0.00256 | 1.85 | Notch homolog 1, translocation-associated (Drosophila) |
| DKK3 | 0.00183 | 1.79 | Dickkopf homolog 3 (Xenopus laevis), transcript variant 1 |
| SMO | 0.00217 | 1.58 | Smoothened homolog (Drosophila) |
| SPRY2 | 0.00332 | 0.67 | Sprouty homolog 2 (Drosophila) |
| NOTCH2 | 0.00014 | 0.64 | Notch homolog 2 (Drosophila) |
| MESP1 | 0.01156 | 0.58 | Mesoderm posterior 1 homolog (mouse) |
| TWIST1 | 0.02902 | 0.53 | Twist homolog 1 |
| MEST | 0.00323 | 0.18 | Mesoderm specific transcript homolog (mouse), transcript variant 1 |
| Growth factor/cell signaling | |||
| IGFBP5 | 0.00856 | 5.23 | Insulin-like growth factor binding protein 5 |
| PDGFD | 0.01156 | 4.85 | Platelet derived growth factor D, transcript variant 1 |
| PDGFD | 0.02023 | 6.47 | Platelet derived growth factor D, transcript variant 2 |
| SOCS1 | 0.00539 | 2.47 | Suppressor of cytokine signaling 1 |
| BMP2K | 0.00001 | 2.25 | BMP2 inducible kinase, transcript variant 2 |
| 1EGFR | 0.00775 | 2.00 | Epidermal growth factor receptor, transcript variant 1 |
| JAK1 | 0.00496 | 1.83 | Janus kinase 1 |
| RARB | 0.00713 | 0.61 | Retinoic acid receptor, beta, transcript variant 1 |
| SMAD7 | 0.00003 | 0.49 | SMAD family member 7 |
| NGF | 0.00143 | 0.34 | Nerve growth factor (beta polypeptide) |
| STAT1 | 0.00658 | 0.33 | Signal transducer and activator of transcription 1, transcript variant α |
| STAT1 | 0.02745 | 0.31 | Signal transducer and activator of transcription 1, transcript variant β |
| Extracellular matrix | |||
| DCN | 0.01358 | 16.00 | Decorin, transcript variant C |
| LAMA2 | 0.03535 | 2.77 | Laminin, alpha 2, transcript variant 1 |
| COL6A3 | 0.00004 | 2.04 | Collagen, type VI, alpha 3 (COL6A3), transcript variant |
| COL5A1 | 0.01064 | 0.62 | Collagen, type V, alpha 1 |
| COL1A1 | 0.01543 | 0.53 | Collagen, type I, alpha 1 |
| LAMC2 | 0.00551 | 0.46 | Laminin, gamma 2, transcript variant 1 |
| FN1 | 0 | 0.22 | Fibronectin 1, transcript variant 6 |
| Inflammation | |||
| PDE5A | 0.02367 | 11.20 | Phosphodiesterase 5A, cGMP-specific, transcript variant 1 |
| PTGER2 | 0.04076 | 4.62 | Prostaglandin E receptor 2 (subtype EP2) |
| IRAK3 | 0.00775 | 3.80 | Interleukin-1 receptor-associated kinase 3 |
| NFKB1 | 0.00144 | 1.79 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| PLCG1 | 0.03371 | 1.51 | Phospholipase C, gamma 1, transcript variant 2 |
| IL1RAP | 0.01188 | 0.58 | Interleukin 1 receptor accessory protein, transcript variant 1 |
| TLR4 | 0.00001 | 0.28 | Toll-like receptor 4 |
| Lipid metabolism | |||
| OLR1 | 0.02776 | 7.27 | Oxidized low density lipoprotein receptor 1 |
| FASN | 0.01645 | 2.23 | Fatty acid synthase |
| ADFP | 0.03652 | 1.66 | Adipose differentiation-related protein |
| Others | |||
| CASP1 | 0.03147 | 7.71 | Caspase 1, apoptosis-related cysteine peptidase |
| CEBPD | 0.00747 | 6.19 | CCAAT/enhancer binding protein, delta |
| ABCC4 | 0 | 4.90 | ATP-binding cassette, sub-family C |
| ADM | 0.02776 | 3.42 | Adrenomedullin |
| HDAC1 | 0.00598 | 1.50 | Histone deacetylase 1 |
| THBS1 | 0.03937 | 0.46 | Thrombospondin 1 |
| ABCA3 | 0.02804 | 0.44 | ATP-binding cassette, sub-family A, member 3 |
| TAGLN | 0.04238 | 0.44 | Transgelin, transcript variant 1, mRNA |
| ODC1 | 0 | 0.42 | Ornithine decarboxylase 1 |
Diff Pval, differential score P value.