Table 3.
Selected Genes Up-Regulated in Neonatal lung Mesenchymal Stromal Cells Relative to Fetal/Neonatal Lung Fibroblasts
| Symbol | Differential score P value | Fold increase | Definition |
|---|---|---|---|
| Growth factor/cell signaling | |||
| PTGS2 | 0.01108 | 3.37 | Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| IRS2 | 0 | 3.24 | Insulin receptor substrate 2 |
| RHOB | 0 | 2.98 | ras homolog gene family, member B |
| POSTN | 0.00002 | 2.64 | Periostin, osteoblast specific factor |
| PDGFRB | 0.02029 | 2.02 | Platelet-derived growth factor receptor, beta polypeptide |
| FZD4 | 0.03599 | 1.99 | Frizzled homolog 4 (Drosophila) |
| BMP2K | 0.00011 | 1.96 | BMP2 inducible kinase, transcript variant 2 |
| ADCY3 | 0.02648 | 1.93 | Adenylate cyclase 3 |
| BMP2K | 0.00309 | 1.74 | BMP2 inducible kinase, transcript variant 1 |
| FYN | 0.00197 | 1.83 | FYN oncogene related to SRC, FGR, YES, transcript variant 3 |
| FYN | 0.0001 | 1.80 | FYN oncogene related to SRC, FGR, YES, transcript variant 2 |
| FYN | 0.01167 | 1.79 | FYN oncogene related to SRC, FGR, YES, transcript variant 1 |
| PIK3R1 | 0.0031 | 1.67 | Phosphoinositide-3-kinase, regulatory subunit 1 (α), transcript variant 1 |
| JAK1 | 0.03598 | 1.63 | Janus kinase 1 |
| TANK | 0.04767 | 1.58 | TRAF family member-associated NFKB activator, transcript variant 1 |
| PTEN | 0.00707 | 1.52 | Phosphatase and tensin homolog |
| ROCK1 | 0.00059 | 1.57 | Rho-associated, coiled-coil containing protein kinase 1 |
| BMP4 | 0.01126 | 0.56 | Bone morphogenetic protein 4, transcript variant 1 |
| SFRP1 | 0.00013 | 0.19 | Secreted frizzled-related protein 1 |
| Transcription | |||
| NKX3-1 | 0.04772 | 2.96 | NK3 homeobox 1 |
| TCF4 | 0.00002 | 2.19 | Transcription factor 4, transcript variant 2 |
| ATF4 | 0.0005 | 2.12 | Activating transcription factor 4, transcript variant 2 |
| GLI2 | 0.00344 | 2.09 | GLI-Kruppel family member GLI2 |
| KLF6 | 0.0292 | 1.91 | Kruppel-like factor 6, transcript variant 1 |
| KLF6 | 0.00381 | 1.88 | Kruppel-like factor 6, transcript variant 2 |
| CREBBP | 0.04601 | 1.64 | CREB binding protein, transcript variant 1 |
| CEBPG | 0.01062 | 1.60 | CCAAT/enhancer binding protein (C/EBP), gamma |
| GLI3 | 0.02884 | 1.63 | GLI-Kruppel family member GLI3 |
| ATF4 | 0.01673 | 1.57 | Activating transcription factor 4, transcript variant 1 |
| HDAC6 | 0.01317 | 1.53 | Histone deacetylase 6 |
| SP3 | 0.00093 | 1.52 | Sp3 transcription factor, transcript variant 2 |
| Extracellular matrix | |||
| COL8A1 | 0.0333 | 2.82 | Collagen, type VIII, alpha 1, transcript variant 2 |
| COL16A1 | 0 | 2.32 | Collagen, type XVI, alpha 1 |
| COL5A2 | 0.00101 | 2.12 | Collagen, type V, alpha 2 |
| COL5A1 | 0.01915 | 2.05 | Collagen, type V, alpha 1 |
| COL3A1 | 0.00002 | 1.97 | Collagen, type III, alpha 1 |
| COL8A1 | 0.04255 | 1.68 | Collagen, type VIII, alpha 1, transcript variant 1 |
| LAMB1 | 0.00984 | 1.56 | Laminin, beta 1 |
| VTN | 0.00739 | 0.56 | Vitronectin |
| Inflammation | |||
| IL8 | 0 | 24.50 | Interleukin 8 |
| IL6 | 0.00772 | 4.26 | Interleukin 6 |
| CXCL2 | 0.01386 | 3.75 | Chemokine (C-X-C motif) ligand 2 |
| NFKB1 | 0.0001 | 1.72 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| F10 | 0.03067 | 1.67 | Coagulation factor X |
| CCL20 | 0.04759 | 1.54 | Chemokine (C-C motif) ligand 20 |
| ADAM17 | 0.01387 | 1.62 | ADAM metallopeptidase domain 17 |
| MMP2 | 0.02185 | 1.53 | Matrix metallopeptidase 2 |
| IL17D | 0.00856 | 0.63 | Interleukin 17D |
| TIMP1 | 0.02736 | 0.57 | TIMP metallopeptidase inhibitor 1 |
| PLAU | 0.01751 | 0.40 | Plasminogen activator, urokinase |
| PTGER2 | 0 | 0.33 | Prostaglandin E receptor 2 (subtype EP2) |
| Lipid metabolism | |||
| FABP3 | 0.0445 | 5.95 | Fatty acid binding protein 3 |
| FADS1 | 0.00047 | 4.16 | Fatty acid desaturase 1 |
| FADS2 | 0.00736 | 3.60 | Fatty acid desaturase 2 (FADS2) |
| LDLR | 0.00001 | 2.61 | Low density lipoprotein receptor |
| FASN | 0.01282 | 2.48 | Fatty acid synthase |
| PPARG | 0 | 0.26 | Peroxisome proliferator-activated receptor gamma, transcript variant 2 |
| Oxidation | |||
| GPX7 | 0.00003 | 3.47 | Glutathione peroxidase 7 |
| NOX4 | 0.04887 | 3.09 | NADPH oxidase 4 |
| SOD2 | 0.03437 | 2.78 | Superoxide dismutase 2, mitochondrial, nuclear gene encoding mitochondrial protein, transcript variant 2 |
| Tight junctions | |||
| CGNL1 | 0.02648 | 3.06 | Cingulin-like 1 |
| PANX2 | 0.00001 | 2.32 | Pannexin 2 |
| TJP1 | 0.00096 | 1.65 | Tight junction protein 1 (zona occludens 1), transcript variant 2 |
| TJP1 | 0.02132 | 1.57 | Tight junction protein 1 (zona occludens 1), transcript variant 1 |
Diff Pval, differential score P value.