Table 2.

Changes in Measures of Skeletal Muscle Mass and Fat Mass by Dual-Energy x-Ray Absorptiometer

Body Composition Measurement (kg)	Testosterone, Mean ± SD			Placebo, Mean ± SD			Treatment Difference, Midtreatment		Treatment Difference, Posttreatment
	Baseline	Midtreatment	Posttreatment	Baseline	Midtreatment	Posttreatment	Mean(CI)	p	Mean(CI)	p
ITT sample	(N = 82)	(N = 73)	(N = 77)	(N = 81)	(N = 75)	(N = 80)
Total lean mass	55.1 ± 6.9	57.2 ± 7.1	56.1 ± 6.9	56.5 ± 6.5	56.7 ± 6.2	56.2 ± 6.3	1.8 (1.2, 2.5)	.2	1.5 (0.4, 2.2)	<.0001
Total fat mass	26.2 ± 7.5	24.9 ± 7.1	24.0 ± 6.8	28 ± 8.4	28 ± 8.1	27.5 ± 7.9	−1.7 (−2.7, −0.6)	.002	−2.0 (−2.8, −1.2)	<.0001
ASMM	23.7 ± 3.3	24.7 ± 3.3	24.2 ± 3.3	24.1 ± 3	24.1 ± 3	23.9 ± 3.1	1.1 (0.7, 1.5)	<.0001	0.9 (0.4, 1.4)	.0009
Appendicular fat mass	9.7 ± 2.8	9.3 ± 2.8	8.9 ± 2.6	10.7 ± 3.5	10.6 ± 3	10.5 ± 3	−0.3 (−0.6, −0.01)	.04	−0.8 (−1.2, −0.4)	.0003
Completion sample	(N = 69)	(N = 62)	(N = 69)	(N = 67)	(N = 63)	(N = 68)
Total lean mass	54.5 ± 7	56.7 ± 7.2	55.7 ± 7.1	57 ± 6.8	57.1 ± 6.5	56.5 ± 6.6	2.0 (1.3, 2.8)	<.0001	1.6 (0.8, 2.4)	<.0001
Total fat mass	25.6 ± 7.4	24.1 ± 6.9	23.5 ± 6.6	28.5 ± 8.6	28.7 ± 8.1	28.1 ± 8	−1.9 (−3.1, −0.6)	<.0001	−2.2 (−1.4, −3.1)	<.0001
ASMM	23.4 ± 3.4	24.5 ± 3.4	24.2 ± 3.4	24.3 ± 3.2	24.3 ± 3.1	24 ± 3.3	1.2 (0.8, 1.6)	<.0001	1.0 (0.4,1.5)	.0004
Appendicular fat mass	9.5 ± 2.9	9.1 ± 2.8	8.7 ± 2.6	10.9 ± 3.6	10.8 ± 3.1	10.7 ± 3	−0.4 (−0.7,− 0.04)	.02	−0.8 (−1.2, −0.4)	.0003

Notes: ASMM = appendicular skeletal muscle mass; CI = confidence interval; ITT = intention to treat.