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. Author manuscript; available in PMC: 2011 Oct 27.
Published in final edited form as: Arch Biochem Biophys. 2010 Mar 3;500(1):3–12. doi: 10.1016/j.abb.2010.02.008

Figure 4.

Figure 4

A close-up view of the CCP active site derived from the 1.2Å structure [27]. Note that Arg48 occupies two positions termed “in’ and “out”. In the “out” position, partially occupied water molecules occupy the space vacated by the Arg48 side chain. Conversely, when Arg48 occupies the “in” position, the vacated “out” space is occupied by water. In Compound I Arg48 is permanently “in” where it is able to H-bond with the ferryl O atom.