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. 2011 Oct 27;7(10):e1002248. doi: 10.1371/journal.pcbi.1002248

Figure 6. Response of the RS-LTS circuits to absence-seizures input from the thalamus.

Figure 6

Additional parameters are g RL = 35, gLR = 7.5, g RR = 0. (A) Response of the circuit to a periodic square input to the RS neurons, mimicking thalamic input during an absence-seizure state (bottom panel). Time courses of M R (top panel) and M L (middle panel) are plotted for I R with amplitude 3.5 and duty cycle of 0.1 (i.e., <I R> = 0.35). The right top and middle panels depict the time course of M R and M L in a shorter time scale to emphasize the temporal form of steady-state activity. (B) <M R>-<I R> curves (top panel) and <M L>-<I R> (bottom panel), representing the steady-state response of the circuit to absence-seizure-like thalamic input to the RS neurons, are plotted for duty cycles of the active phase of 0.1 (black) and 0.5 (red).