Table 1. Clinical and Demographic Characteristics of 28 Patients with Suspected Mucosal Leishmaniasis.
| Age, Sex | Lesion Location | Intercurrent CL* | LST | Histopathology | PCR Biopsy | PCR Brush** |
| 60, M§ | NS | No | Pos | Lymphoeosinophilic infiltrate | Pos | Pos |
| 46, M¶ | NS | No | Neg | Granulomatous inflammation | Pos | Pos |
| 62, F | NS | No | Neg | Lymphoplasmo-histiocytosis | Pos | Pos |
| 68, M | NS | Yes | Neg | Lymphoeosinophilic infiltrate | Pos | Pos† |
| 66, M§ | NS | No | Pos | Parasitic granuloma with amastigotes | Pos | Pos |
| 57, M | Canthus | Yes | Pos | Granulomatous inflammation with amastigotes present | Pos | Pos |
| 36, M | NS | Yes | Pos | Normal cartilage | Pos | Pos |
| 49, F¶ | NS | No | Neg | Polymorphonuclear lymphocytic infiltrate | Pos | Pos |
| 75, F | NS | Yes | Pos | Lymphocytic infiltrate | Pos | Pos |
| 16, M | NS | No | Pos | Parasitic granuloma with amastigotes | Pos | Pos |
| 38, M§ | Buccal | No | Neg | PAS-positive bodies suspicious for Paracoccidioides braziliensis infection | Pos | Pos |
| 31, M§ | Hard Palate | No | Neg | Granulomatous inflammation | Pos | Pos |
| 87, M§ | Buccal | No | Neg | Epidermoid carcinoma | Neg | Neg |
| 52, M§ | NS | No (stasis ulcers) | Pos | Granulomatous inflammation | Pos | Pos |
| 63, M¶ | NS | No | Pos | Granulomatous inflammation | Pos | Pos |
| 32, M§ | NS | No | Pos | Granulomatous inflammation | Pos | Neg |
| 19, M | NS | No | Neg | Perivascular eosinophilic infiltrate | Neg | Neg |
| 41, M | Hard Palate | No | Pos | Granulomatous inflammation | Pos | Pos |
| 40, M§ | NS | No | Neg | Granulomatous inflammation | Neg | Pos |
| 20, F§ | NS | No | Pos | Granulomatous inflammation | Pos | Pos |
| 50, M§ | NS | No | Pos | Granulomatous inflammation | Neg | Pos |
| 47, M§ | NS | No | Pos | Parasitic granuloma with amastigotes | Pos | Pos |
| 62, F¶ | NS | No | Neg | Acute and chronic inflammatory infiltrate | Neg | Neg |
| 43, M§ | NS | No | Pos | Parasitic granuloma with amastigotes | Pos | Pos |
| 62, M | NS | No | Neg | Granulomatous inflammation | Neg | Neg |
| 35, M§ | NS | No | Neg | Granulomatous inflammation | Pos | Pos |
| 55, M§ | NS | No | Pos | Granulomatous inflammation | Pos | Pos |
| 23, M§ | NS | No | Pos | Epithelial hyperplasia and necrosis | Pos | Pos |
*Intercurrent CL confirmed by smear or culture of cutaneous lesion specimens.
**All 5 control volunteers had negative cytology brush specimens.
†
CerviSoft® and Histobrush® PCR demonstrated 97% concordance; in 1 patient, CerviSoft® PCR was positive and Histobrush® PCR was negative.
§
Patient with known previous CL on history.
¶
Patient with scars suspicious to be healed CL but no definitive history of diagnosis.
Abbreviations: CL, cutaneous leishmaniasis; F, female; LST, leishmanin skin test; M, male; Neg, negative; NS, nasal septum; Pos, positive.