Table 2. Analysis of 5 Diagnostic Tests used in the Evaluation of 28 Patients with Suspected Mucosal Leishmaniasis.
Assay | Number Positive | Number Negative | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
kDNA PCR of Biopsy Specimen | 22 | 6 | 95.7 | 100.0 | 100.0 | 83.3 |
kDNA PCR of CerviSoft® brushes | 23 | 10* | 95.7 | 90.0 | 95.7 | 90.0 |
kDNA PCR of Histobrush® brushes | 22 | 11* | 91.3 | 90.0 | 95.5 | 81.8 |
LST | 16 | 12 | 69.6 | 100.0 | 100.0 | 41.7 |
Biopsy with Histopathology | 5 | 23 | 21.7 | 100.0 | 100.0 | 21.7 |
*includes nasal and buccal specimens from 5 healthy control volunteers.
Abbreviations: LST, leishmanin skin test; NPV, negative predictive value; PPV, positive predictive value.