Table 1. Enriched GO terms for biological process based on variable genes in lung cancer tissues when compared with their adjacent normal tissues.
| Class | GO terms | GO number | Statistic* |
| Up-regulated | DNA metabolic process | GO:0006259 | C = 552;O = 27;E = 9.68;R = 2.79;rawP = 1.48e-06;adjP = 0.0008 |
| Up-regulated | M phase | GO:0000279 | C = 370;O = 21;E = 6.49;R = 3.24;rawP = 2.35e-06;adjP = 0.0008 |
| down-regulated | immune response | GO:0006955 | C = 750;O = 101;E = 42.54;R = 2.37;rawP = 1.51e-16;adjP = 2.91e-13 |
| down-regulated | immune system process | GO:0002376 | C = 1066;O = 124;E = 60.46;R = 2.05;rawP = 3.98e-15;adjP = 3.84e-12 |
| down-regulated | defense response | GO:0006952 | C = 657;O = 89;E = 37.26;R = 2.39;rawP = 8.14e-15;adjP = 5.23e-12 |
| down-regulated | inflammatory response | GO:0006954 | C = 359;O = 60;E = 20.36;R = 2.95;rawP = 2.82e-14;adjP = 1.36e-11 |
| down-regulated | response to wounding | GO:0009611 | C = 560;O = 75;E = 31.76;R = 2.36;rawP = 2.23e-12;adjP = 8.60e-10 |
| down-regulated | response to stress | GO:0006950 | C = 1696;O = 147;E = 96.19;R = 1.53;rawP = 5.52e-08;adjP = 1.33e-05 |
| down-regulated | innate immune response | GO:0045087 | C = 176;O = 30;E = 9.98;R = 3.01;rawP = 5.52e-08;adjP = 1.33e-05 |
| down-regulated | response to external stimulus | GO:0009605 | C = 904;O = 91;E = 51.27;R = 1.77;rawP = 4.51e-08;adjP = 1.33e-05 |
| down-regulated | immune effector process | GO:0002252 | C = 200;O = 31;E = 11.34;R = 2.73;rawP = 3.06e-07;adjP = 6.56e-05 |
| down-regulated | regulation of immune system process | GO:0002682 | C = 362;O = 45;E = 20.53;R = 2.19;rawP = 5.72e-07;adjP = 0.0001 |
| down-regulated | leukocyte mediated immunity | GO:0002443 | C = 126;O = 22;E = 7.15;R = 3.08;rawP = 2.14e-06;adjP = 0.0002 |
| down-regulated | actin cytoskeleton organization | GO:0030036 | C = 257;O = 35;E = 14.58;R = 2.40;rawP = 1.28e-06;adjP = 0.0002 |
| down-regulated | positive regulation of immune system process | GO:0002684 | C = 229;O = 32;E = 12.99;R = 2.46;rawP = 2.08e-06;adjP = 0.0002 |
| down-regulated | lymphocyte activation | GO:0046649 | C = 272;O = 36;E = 15.43;R = 2.33;rawP = 1.80e-06;adjP = 0.0002 |
| down-regulated | T cell activation | GO:0042110 | C = 194;O = 29;E = 11.00;R = 2.64;rawP = 1.57e-06;adjP = 0.0002 |
| down-regulated | leukocyte activation | GO:0045321 | C = 324;O = 41;E = 18.38;R = 2.23;rawP = 1.15e-06;adjP = 0.0002 |
| down-regulated | actin filament-based process | GO:0030029 | C = 274;O = 36;E = 15.54;R = 2.32;rawP = 2.14e-06;adjP = 0.0002 |
| down-regulated | adaptive immune response | GO:0002250 | C = 113;O = 20;E = 6.41;R = 3.12;rawP = 4.97e-06;adjP = 0.0005 |
| down-regulated | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | GO:0002460 | C = 112;O = 20;E = 6.35;R = 3.15;rawP = 4.31e-06;adjP = 0.0005 |
| down-regulated | lymphocyte mediated immunity | GO:0002449 | C = 106;O = 19;E = 6.01;R = 3.16;rawP = 7.04e-06;adjP = 0.0007 |
| down-regulated | positive regulation of biological process | GO:0048518 | C = 1865;O = 148;E = 105.77;R = 1.40;rawP = 9.03e-06;adjP = 0.0008 |
| down-regulated | cell activation | GO:0001775 | C = 366;O = 42;E = 20.76;R = 2.02;rawP = 1.05e-05;adjP = 0.0009 |
*The alst column lists the number of reference genes in the category (C), number of genes in the gene set and also in the category (O), expected number in the category (E), Ratio of enrichment (R), p value from hypergeometric test (rawP), and p value adjusted by the multiple test adjustment (adjP).