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. 2011 Oct 27;6(10):e26604. doi: 10.1371/journal.pone.0026604

Figure 1. Tyrosine degradation pathway and cluster organization.

Figure 1

(A) Enzymes involved in degradation of L-phenylalanine and L-tyrosine are phenylalanine hydroxylase (PhhA), tyrosine aminotransferase (Tat), p-hydroxyphenylpyruvate dioxygenase (HppD), homogentisate dioxygenase (HmgA), 4-maleylacetoacetate isomerase (MaiA) and 4-fumarylacetoacetate hydrolase (FahA). Oxidation (O) and polymerization of homogentisate leads to formation of pyomelanin. (B) The tyrosine degradation cluster in A. fumigatus [13] encodes four enzymes involved in degradation of tyrosine as well as HmgX (AFUA_2G04210) and the transcriptional regulator HmgR (AFUA_2G04262). Genes are indicated as arrows.