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. 2011 Oct 27;6(10):e26604. doi: 10.1371/journal.pone.0026604

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Keller et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The wild type (WT) and the ΔhmgX mutant were cultivated with (+) or without (-) addition of tyrosine. At the time points indicated, samples of the culture supernatant were taken and analyzed by HPLC to quantify formation of p-hydroxyphenylpyruvate (pHPP) and homogentisate (HGA). (B) Strains ΔhmgA and ΔhmgX/ΔhmgA were cultivated in presence of tyrosine. Conversion of pHPP to HGA by protein crude extracts was monitored by HPLC.