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. 2011 Oct 27;6(10):e26897. doi: 10.1371/journal.pone.0026897

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Savic et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A)–(C) Open field testing. (A) Center time shown as a percent of total time (%) in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (B) Total distance shown in meters (m) in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (C) Latency to periphery shown in seconds (s) in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (D)–(F) Light dark box testing. (D) Time in light shown as a percent of total time (%) in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (E) Number of transitions between the light and dark compartments in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (F) Latency to the dark compartment shown in seconds (s) in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (G) – (I) Fear conditioning. (G) Contextual fear shown as a percent time spent freezing (%) in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (H) Cue-based fear shown as a percent time spent freezing (%) in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (I) Pre-training freezing shown as a percent time spent freezing (%) in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. (J) Prepulse inhibition in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. Prepulse inhibition (%) using prepulses of 3, 6 and 12 decibels (dB) are shown. (K) Startle response in wild-type (WT, n = 9) and BAC transgenic (BAC, n = 9) mice. Wild-type data are shown in gray while BAC transgenic data are shown in orange.