Table 1.
Descriptive demographic, clinical and laboratory data according to the left ventricular geometric pattern at the first evaluation. Only significant differences (p < 0.05) or statistical tendencies (p in the range 0.05–0.1) are shown
| NG1 42 (48.9%) | CR1 4 (4.6%) | CH1 8 (9.3%) | EH1 32 (37.2%) | p | |
|---|---|---|---|---|---|
| Birth weight (g) | 3,400 (1,410–4,100) | 3,495 (3,130–3,850) | 3875 (2850–5300) | 3300 (2100–5250) | NG1 vs CH1 < 0.01 CH1 vs EH1< 0.11 |
| BMI (kg/m2) | 23.9 (15.2–39.7) | 20.7 (18.9–22.8) | 25.9 (21.9–27.9) | 27.1 (19.8–39.1) | NG1, CR1 vs EH1 < 0.05 |
| WC (cm) | 78 (53–98.5) | 75 (67–80) | 87 (78–96) | 93 (66–111) | NG1 vs CH1, EH1 < 0.05, CR1 vs CH1, EH1 < 0.05 |
| WHR | 0.81 (0.72–0.91) | 0.89 (0.78–0.97) | 0.87 (0.78–1.03) | 0.88 (0.73–1.03) | NG1 vs EH1 < 0.01, NG1 vs CH1 = 0.07 |
| Patients with ambulatory hypertension (%) | 29 (69%) | 2 (50%) | 4 (50%) | 15 (46.8%) | NG1 vs EH1 0.05, Chi-squared = 3.70 |
| Patients with severe ambulatory hypertension | 13 (31%) | 2 (50%) | 4 (50%) | 17 (53.1%) | NG1 vs EH1 0.05, Chi-squared = 3.70 |
| Total cholesterol (mg/dl) | 178 (100–290) | 192 (181–243) | 177 (130–205) | 168 (94–236) | CR1 vs EH1 < 0.05 |
| HDL (mg/dl) | 44 (25–58) | 49 (46–50) | 44 (22–66) | 42 (29–61) | CR1 vs EH1 < 0.05 |
| HbA1C (%) | 5.4 (4.5– 6.7) | 4.9 (4.2–5.0) | 5.0 (4.4–5.4) | 5.3 (4.1–6.8) | CR1 vs NG1 0.05, vs EH1 0.06 |
| Insulin[0] (mU/ml) | 13 (5.6–31 ) | 13.5 (5–16) | 11.7 (9.3–39) | 13.6 (7.5–48) | CH1 vs CR1 0.10, CH1 vs EH1 0.11 |
| Uric acid (mg/dl) | 5.4 (2.7–8.6) | 5 (4.2–5.6) | 5.6 (3.2 –7.5) | 5.6 (3.2–8.3) | ns |
| GPX (U/g Hb) | 31.2 (26.1–39.9) | 30.2 (25.4–31.6) | 32.6 (29.1–38.7) | 31.8 (26.2–38.1) | CR1 vs CH1 < 0.05, CR1 vs EH1 0.06 |
| Thiobarbiturate reactive substance (μmol/l) | 0.24 (0.16–1.25) | 0.42 (0.34–0.62) | 0.30 (0.14–1.28) | 0.32 (0.18–1.25) | NG1 vs CR1, EH1< 0.05 |
| Overweight and obese patients (%) | 23 (54.8%) | 1 (25%) 0 | 8 (100%) | 26 (81.2%) | NG1 vs EH1 0.01 Chi-squared = 5.7, NG1 vs CH1 0.04, Chi-squared = 4.07, CR1 vs CH1 0.03, Chi-squared = 4.50 |
NG1, normal geometry at start of treatment; CR1, concentric remodeling at start of treatment; CH1, concentric hypertrophy at start of treatment; EH1, eccentric hypertrophy at start of treatment; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; HbA1C, glycated hemoglobin; glucose[0], fasting glucose concentration; GPX, glutathione peroxidase activity