Figure 3.

Map of the SNPs genotyped and tested within and adjacent to C21orf91.The C21orf91 gene spans 30 300 bp of chromosome 21. It is transcribed from the minus strand (right to left in this figure). The locations of the 6 single nucleotide polymorphisms (SNPs) presented in Table 1 are indicated by arrows. Nonsynonymous (amino acid–changing) SNPs are shown (D136E and N115K). The SNPs labeled in boldface type were associated with the cold-sore phenotype by linkage or transmission disequilibrium testing. The distance along the chromosome in kb is shown.