Table 1.
Relationship Between Interleukin (IL) 18 and IL-28B Single-Nucleotide Polymorphisms and Plasma IL-18a
| Persistent infection |
Spontaneous clearance |
||||
| SNP | Preinfection IL-18 (pg/mL) | Peak IL-18 (pg/mL) | Preinfection IL-18 (pg/mL) | Peak IL-18 (pg/mL) | |
| rs187238 (−137) | GG | 102 ± 15 | 323 ± 76 | 71 ± 14 | 360 ± 52 |
| GC + CC | 92 ± 11 | 349 ± 68 | 74 ± 9 | 348 ± 54 | |
| rs1946518 (−607) | CC | 105 ± 17 | 301 ± 66 | 73 ± 16 | 368 ± 59 |
| CA + AA | 94 ± 11 | 360 ± 67 | 73 ± 9 | 347 ± 48 | |
| rs12979860 | CC | 94 ± 13 | 363 ± 77 | 75 ± 10 | 351 ± 54 |
| CT + TT | 101 ± 15 | 318 ± 64 | 92 ± 9 | 368 ± 46 | |
Abbreviations: HCV, hepatitis C virus; IL, interleukin; SNP, single-nucleotide polymorphism.
a
At preinfection and at the time point at which peak IL-18 was detected in subjects with chronic HCV infection and in subjects who spontaneously cleared HCV infection.