Table 2.
Kinetics of 10,12 CLA-mediated suppression of transcription factors or enzymes that regulate lipogenesis and lipid metabolism in human adipocytes.
| ↓Regulators of Lipogenesis by CLA | ↓Lipid Metabolism by CLA | ||||
|---|---|---|---|---|---|
| mRNA or Protein | De novo synthesis | MUFA/SFA Ratio | Total Lipids | ||
| 5–12 h | 3 h | 24 h | 72 h | 24 h | 72 h |
| LXRa | TG | CE | PA | C14:1/C14:0 | Total lipids |
| SREBP-1c | DAG | C16:1/C16:0 | |||
| PPARγ | FFA | C18:1/C18:0 | |||
| SCD-1 | PC | ||||
| CL | |||||
| CER | |||||
Abbreviations used: LXRa, liver X receptor a; SREBP-1c, sterol regulatory element binding protein-1c; PPARγ, peroxisome proliferator activated receptor γ; SCD-1, stearoyl CoA desaturase-1; TG, triglyceride; DAG, diacylglycerol; FFA, free fatty acid; PC, phosphatidylcholine; CL, cardiolipin; CER, ceramide; CE, cholesterol ester; PA, phosphatidic acid; TL, total lipids.