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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Hepatology. 2011 Nov;54(5):1753–1766. doi: 10.1002/hep.24540

Fig.4.

Fig.4

Oxidative stress. (A) Thiobarbituric acid reactive substances (TBARS), expressed as malondialdehyde (MDA) equivalents. ** p<0.01 compared to the WT and JNK2 KO mice treated with pyrazole plus TNF-α. ## p<0.01 compared to pyrazole or TNF-α alone, (B) GSH in liver homogenates. ** p<0.01 and *** p<0.001 compared to the JNK1 KO treated with pyrazole plus TNF-α. (C) 4-HNE adducts. C3 and C6 show strong 4-HNE positive staining in hepatocytes from the pyrazole plus TNF-α treated WT mice and JNK2 KO mice (+++, arrows, IHC×300). C9 show weak 4-HNE positive staining in the JNK1 KO group (+, IHC×300). (D) iNOS. D3 and D6 (++-+++, arrows). D9 (+). (E) 3-NT adducts. E3 and E6 show moderate to strong 3-NT positive staining in hepatocytes from the WT and JNK2 KO mice (++-+++, arrows). E9 shows weak 3-NT positive staining in the JNK1 KO group (+).