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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Am J Transplant. 2011 Aug 3;11(11):2332–2341. doi: 10.1111/j.1600-6143.2011.03676.x

Figure 3. TGF-β expression is diminished in rejecting artery grafts.

Figure 3

SCID-beige mouse recipients of human coronary artery grafts (n=9 from 5 artery donors) received 1.5×108 allogeneic human PBMC (from one of 2 PBMC donors) at 1 wk post-op and were treated with IgG or TGF-β antibody at 250 μg s.c., 3x per wk, from 1 to 5 wk post-op. The artery grafts were procured at 5 wk post-op and the abundance of transcripts for (A) TGF-β1, TGF-β2, TGF-β3, (B) CD31, SMA, CD3ε, (C) IL-6, IL-8, and IP-10 normalized to GAPDH were measured by quantitative RT-PCR. *P<0.05, TGF-β Ab or IgG vs. No treatment, +P<0.05, TGF-β Ab vs. IgG, one-way ANOVA.