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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Am J Transplant. 2011 Aug 3;11(11):2332–2341. doi: 10.1111/j.1600-6143.2011.03676.x

Figure 4. TGF-β inhibits IFN-γ production in rejecting artery grafts.

Figure 4

SCID-beige mouse recipients of human coronary artery grafts (n=17 from 9 artery donors) received 0.5-3×108 allogeneic human PBMC (from one of 3 PBMC donors) at 1 wk post-op and were treated with IgG or TGF-β antibody at 250 μg s.c., 3x per wk, from 1 to5 wk post-op. The artery grafts were procured at 5 wk post-op and the abundance of T cell-associated transcripts for (A) IFN-γ, IL-4, IL-10, IL-17, (B) T-bet, GATA-3, Foxp3, and RORC normalized to GAPDH were measured by quantitative RT-PCR. +P<0.05, TGF-β Ab vs. IgG, paired t test.