Table 6.
Established pancreas gene regulatory relationships that are identified by BN modeling
| Known regulatory relationship | Identified by BN modeling with prior knowledge | Identified by the plain BN without prior knowledge |
|---|---|---|
| Hes1→Neurog3 | √ | |
| Hnf4a→Tcf1 | √ | √ |
| Pdx1→Gck | √ | |
| Pdx1→Hnf4a | ||
| Pdx1→Iapp | ||
| Pdx1→Ins2 | √ | |
| Pdx1→Nr5a2 | √ | √ |
| Mafb→Ins2 | ||
| Mafb→Pdx1 | ||
| Neurog3→Nkx2-2 | √ | |
| Nkx2-2→Gck | √ | √ |
| Nkx2-2→Iapp | ||
| Nkx2-2→Ins2 | ||
| Onecut1→Pdx1 | ||
| Onecut1→Neurog3 | ||
| Onecut1→Tcf1 | √ | |
| Pax6→Gck | ||
| Pax6→Iapp | √ | √ |
| Pax6→Ins2 | √ | √ |
| Pax6→Pdx1 | √ | √ |
| Tcf1→Hnf4a | ||
| Tcf1→Pdx1 | ||
| Tcf1→Pklr | ||
| Tcf1→Slc2a2 | √ |
BN with prior knowledge can recover half of the experimentally confirmed transcriptional regulations during mouse pancreas development, two times more than the plain BN without prior knowledge.