Table 3.

Distribution of 275 Dot/Icm substrates identified in strain L. pneumophila Philadelphia in the 5 sequenced L. pneumophila and 5 sequenced L. longbeachae strains.

L. pneumophila						L. longbeachae					Name	Product
Phila	Paris	Lens	Corby	Alcoy	130b	NSW 150	D-4968	AT	98072	C-4E7
lpg0008	lpp0008	lpl0008	lpc0009	lpa0011	lpw00071	–	–	−	−	−	ravA	Unknown
lpg0012	lpp0012	lpl0012	lpc0013	lpa0016	lpw00111	–	–	−	−	−	cegC1	Ankyrin
lpg0021	lpp0021	lpl0022	lpc0022	lpa0030	lpw00221	llo0047	llb1841	+	+	+	–	Unknown
lpg0030	lpp0030	lpl0031	lpc0031	lpa0040	lpw00311	–	–	−	−	−	ravB	Unknown
lpg0038	lpp0037	lpl0038	lpc0039	lpa0049	lpw00381	–	–	−	−	−	ankQ/legA10	Ankyrin repeat
lpg0041	–	–	lpc0042	lpa0056	–	–	–	−	−	−	–	Putative metalloprotease
lpg0045	lpp0046	lpl0044	lpc0047	lpa0060	lpw00441	–	–	−	−	−	–	Unknown
lpg0046	lpp0047	lpl0045	lpc0048	lpa0062	lpw00451	–	–	−	−	−	–	Unknown
lpg0059	lpp0062	lpl0061	lpc0068	lpa0085	lpw00621	–	–	−	−	−	ceg2	Unknown
lpg0080	lpp0094	–	–	lpa3018	lpw00781	–	–	−	−	−	ceg3	Unknown
lpg0081	lpp0095	–	–	–	lpw00791	–	–	−	−	−	–	Unknown
lpg0090	lpp0104	lpl0089	lpc0109	lpa0132	lpw00881	–	–	−	−	−	lem1	Unknown
lpg0096	lpp0110	lpl0096	lpc0115	lpa0145	lpw00961	llo1322	llb0347	+	+	+	ceg4	Unknown
lpg0103	lpp0117	lpl0103	lpc0122	lpa0152	lpw01031	llo3312	llb2028	+	+	+	vipF	N-terminal acetyl-transferase, GNAT
lpg0126	lpp0140	lpl0125	lpc0146	lpa0185	lpw01261	–	–	−	−	−	cegC2	Ninein
lpg0130	lpp0145	lpl0130	lpc0151	lpa0194	lpw01311	llo3270	llb2073	+	+	+	–	Unknown
lpg0135	lpp0150	lpl0135	lpc0156	lpa0204	lpw01361	llo2439	llb2921	+	+	+	sdhB	Unknown
lpg0160	lpp0224	lpl0224	lpc0242	lpa0322	lpw02541	–	–	−	−	−	ravD	Unknown
lpg0170	lpp0232	lpl0233	lpc0251	lpa0335	lpw02641	llo1378	llb0280	+	+	+	ravC	Unknown
lpg0171	lpp0233	lpl0234	–	–	lpw02651	–	–	−	−	−	legU1	F-box motif
lpg0172	lpp0234	–	lpc0253	lpa0339	lpw02661	–	–	−	−	−	–	Unknown
lpg0181	lpp0245	lpl0244	lpc0265	lpa0388	lpw02761	llo2453	llb2907	+	+	+	–	Unknown
lpg0191	lpp0251	–	–	–	lpw02821	–	–	−	−	−	ceg5	Unknown
lpg0195	lpp0253	lpl0251	lpc0272	lpa0339	lpw02851	–	–	−	−	−	ravE	Unknown
lpg0196	lpp0254	lpl0252	–	–	lpw02861	llo2549	llb2798	+	+	+	ravF	Unknown
lpg0210	lpp0269	lpl0264	lpc0285	lpa0388	lpw02981	–	–	−	−	−	ravG	Unknown
lpg0227	lpp0286	lpl0281	lpc0303	lpa0412	lpw03151	llo2491	llb2864	+	+	+	ceg7	Unknown
lpg0234	lpp0304	lpl0288	lpc0309	lpa0419	lpw03221	llo0425	llb1431	+	+	+	sidE/laiD	Unknown
lpg0240	lpp0310	lpl0294	lpc0316	lpa0428	lpw03291	llo1601	llb0040	+	+	+	ceg8	Unknown
lpg0246	lpp0316	lpl0300	lpc0323	lpa0436	lpw03361	–	–	−	−	−	ceg9	Unknown
lpg0257	lpp0327	lpl0310	lpc0334	lpa0450	lpw03461	llo2362	llb3009	+	+	+	sdeA	Multidrug resistance protein
lpg0260	lpp0332	lpl0313	lpc0337	lpa0456	lpw03491	–	–	−	−	−	–	Unknown
lpg0275	lpp0349	lpl0327	lpc0351/3529	lpa0477	lpw03641	–	–	−	−	−	sdbA	Unknown
lpg0276	lpp0350	lpl0328	lpc0353	lpa0479	lpw03651	llo0327	llb1533	+	+	+	legG2	Ras guanine nucleotide exchange factor
lpg0284	lpp0360	lpl0336	lpc0361	lpa0490	lpw03741	–	–	−	−	−	ceg10	Unknown
lpg0285	lpp0361	lpl0337	lpc0362	lpa0492	lpw03751	–	–	−	−	−	lem2	Unknown
lpg0294	lpp0372	lpl0347	lpc0373	lpa0508	lpw03861	llo0464	llb1386	+	+	+	–	Unknown
lpg0364	lpp0429	lpl0405	lpc2980	lpa0578	lpw04431	–	–	−	−	−	–	Unknown
lpg0365	lpp0430	lpl0406	lpc2979	lpa0580	lpw04441	llo0525	llb1334	+	+	+	–	Unknown
lpg0375	lpp0442	lpl0418	lpc2968	lpa0596	–	–	–	−	−	−	–	Unknown
lpg0376	lpp0443	lpl0419	lpc2967	lpa0597	lpw04591	llo0548	llb1307	+	+	+	sdhA	GRIP, coiled-coil
lpg0390	lpp0457	lpl0433	lpc2954	lpa0613	lpw04721	–	–	−	−	−	vipA	Unknown
lpg0401	lpp0468	lpl0444	lpc2942	lpa0629	lpw04831	llo2582	llb2763	+	+	+	legA7/ceg11	Unknown
lpg0402	–	–	–	–	–	–	–	−	−	−	ankY/legA9	Ankyrin, STPK
lpg0403	lpp0469	lpl0445	lpc2941	lpa0630	lpw04841	–	–	−	−	−	ankG/ankZ/legA7	Ankyrin
lpg0405	lpp0471	lpl0447	lpc2939	lpa0633	lpw04861	llo2845	llb2472	+	+	+	–	Spectrin domain
lpg0422	lpp0489	lpl0465	lpc2921	lpa0657	lpw05041	llo2801	llb2523	+	+	+	legY	Putative Glucan 1,4-alpha-glucosidase
lpg0436	lpp0503	lpl0479	lpc2906	lpa0673	lpw05181	–	–	−	−	−	ankJ/legA11	Ankyrin
lpg0437	lpp0504	lpl0480	lpc2905	lpa0674	lpw05191	–	–	−	−	−	ceg14	Unknown
lpg0439	lpp0505	lpl0481	lpc2904	lpa0678	lpw05201	llo2983	llb2392	+	+	+	ceg15	Unknown
lpg0483	lpp0547	lpl0523	lpc2861	lpa0739	lpw05631	llo2705	llb2623	+	+	+	ankC/legA12	Ankyrin
lpg0515	lpp0578	lpl0554	lpc2829	lpa0776	lpw05951	llo3224	llb2129	+	+	+	legD2	Phytanoyl-CoA dioxygenase domain
lpg0518	lpp0581	lpl0557	lpc2826	lpa0781	lpw05981	–	–	−	−	−	–	Unknown
lpg0519	–	–	–	–	–	–	–	−	−	−	ceg17	Unknown
lpg0621	lpp0675	lpl0658	lpc2673	lpa0975	lpw06951	–	–	−	−	−	sidA	Unknown
lpg0634	lpp0688	lpl0671	lpc2660	lpa0996	lpw07081	llo2574	llb2771	+	+	+	–	Unknown
lpg0642	lpp0696/97	lpl0679	lpc2651	lpa1005	lpw07161	–	–	−	−	−	wipB	Unknown
lpg0695	lpp0750	lpl0732	lpc2599	lpa1082	lpw07721	–	–	−	−	−	ankN/ankX legA8	Ankyrin
lpg0696	lpp0751	lpl0733	lpc2598	lpa1084	lpw07731	–	–	−	−	−	lem3	Unknown
lpg0716	lpp0782	lpl0753	lpc2577	lpa1108	lpw07931	–	–	−	+	+	–	Unknown
lpg0733	lpp0799	lpl0770	lpc2559	lpa1135	lpw08111	llo0831	llb0892	+	+	+	ravH	Unknown
lpg0796	lpp0859	–	–	–	–	–	–	−	−	−	–	Unknown
lpg0898	lpp0959	lpl0929	lpc2395	lpa1360	lpw09801	–	–	−	−	−	ceg18	Unknown
lpg0926	lpp0988	lpl0957	lpc2365	lpa1397	lpw10111	–	–	−	−	−	ravI	Unknown
lpg0940	lpp1002	lpl0971	lpc2349	lpa1415	lpw10251	–	–	−	−	−	lidA	Unknown
lpg0944	lpp1006	–	lpc2345	lpa1421	–	–	–	−	−	−	ravJ	Unknown
lpg0945	lpp1007	lpl1579	lpc2344	lpa1423	lpw10311	–	–	−	−	−	legL1	LLR
lpg0963	lpp1025	lpl0992	lpc2324	lpa1453	lpw10491	llo0934	llb0782	+	+	+	–	Unknown
lpg0967	lpp1029	–	lpc2320	lpa1459	lpw10531	–	–	−	−	−	–	Unknown
lpg0968	lpp1030	lpl0997	lpc2319	lpa1460	lpw10541	–	–	−	−	−	sidK	Unknown
lpg0969	lpp1031	lpl0998	lpc2318	lpa1461	lpw10551	llo3265	llb2078	+	+	+	ravK	Unknown
lpg1083	–	–	–	–	–	–	–	−	−	−	–	Unknown
lpg1101	lpp1101	lpl1100	lpc2154*	lpa1709	lpw11451	–	–	−	−	−	lem4	Unknown
lpg1106	lpp1105	lpl1105	lpc2149	lpa1719	lpw11501	llo1414	llb0239/40	+	+	+	–	Unknown
lpg1108	lpp1108	lpl1108	lpc2146	lpa1724	lpw11531	llo3030	llb2350	+	+	+	ravL	Unknown
lpg1109	lpp1109	–	lpc2145	lpa1725	–	–	–	−	−	−	ravM	Unknown
lpg1110	lpp1111	lpl1114	lpc2142	lpa1728	lpw11571	–	–	−	−	−	lem5	Unknown
lpg1111	lpp1112	lpl1115	lpc2141	lpa1730	lpw11581	llo3126	llb2244	+	+	+	ravN	Unknown
lpg1120	–	–	–	–	lpw11681	–	–	−	−	−	lem6	Unknown
lpg1121	lpp1121	lpl1126	lpc0578	lpa1743	lpw11691	llo1321	llb0348	+	+	+	ceg19	Unknown
lpg1124	lpp1125	lpl1129	lpc0582	lpa1748	lpw11741	llo3206	llb2150	+	+	+	–	Unknown
lpg1129	lpp1130	–	–	–	lpw11801	–	–	−	−	−	ravO	Unknown
lpg1137	lpp1139	lpl1144	lpc0601	lpa1776	lpw11901	llo2404	llb2962	+	+	+	–	Unknown
lpg1144	lpp1146	lpl1150	lpc0607	lpa1785	lpw11971	–	–	−	−	−	cegC3	Unknown
lpg1145	lpp1147	lpl1151	lpc0608	lpa1787	lpw11981	–	–	−	−	−	lem7	Unknown
lpg1147	lpp1149	lpl1153	lpc0610	lpa1789	lpw12001	–	–	−	−	−	–	GCN5-related N-acetyltransferase
lpg1148	lpp1150	lpl1154	lpc0611	lpa1790	lpw12011	–	–	−	−	−	–	Unknown
lpg1152	lpp1154	lpl1159	lpc0615	lpa1795	lpw12061	–	–	−	−	−	ravP	Unknown
lpg1154	lpp1156	lpl1161	lpc0617	lpa1797	lpw12081	llo2487	llb2868	+	+	+	ravQ	Unknown
lpg1158	lpp1160	lpl1165*	lpc0621	lpa1802	lpw12121	–	–	−	−	−	–	Unknown
lpg1166	lpp1168	lpl1174	lpc0631	lpa1819	lpw12211	llo1034	llb0680	+	+	+	ravR	Unknown
lpg1171	lpp1173	lpl1179	lpc0637	lpa1826	–	–	–	−	−	−	–	Spectrin domain
lpg1183	lpp1186	lpl1192	lpc0650	lpa1839	lpw12401	llo2390	llb2978	+	+	+	ravS	Unknown
lpg1227	lpp1235	lpl1235	lpc0696	lpa1899	lpw12861	–	–	−	−	−	vpdB	Unknown
lpg1273	lpp1236	lpl1236	lpc0698	lpa1901	lpw12871	–	–	−	−	−	–	Unknown
lpg1290	lpp1253	–	–	–	–	–	–	−	−	−	lem8	Unknown
lpg1312	–	–	–	–	lpw13261	–	–	−	−	−	legC1	Unknown
lpg1316	–	–	–	–	–	llo1389	llb0269	+	+	+	ravT	Unknown
lpg1317	–	–	–	–	–	–	–	−	−	−	ravW	Unknown
lpg1328	lpp1283	lpl1282	lpc0743	lpa1958	–	–	–	−	−	−	legT	Thaumatin domain
lpg1355	lpp1309	–	–	–	–	–	–	−	−	−	sidG	Coiled-coil
lpg1426	lpp1381	lpl1377	lpc0842	lpa2090	lpw14431	llo1791	llb3606	+	+	+	vpdC	Patatin domain
lpg1449	lpp1404	–	–	–	lpw14671	–	–	−	−	−	–	Unknown
lpg1453	lpp1409	lpl1591	lpc0868	lpa2119	lpw14711	–	–	−	−	−	–	Unknown
lpg1483	lpp1439	lpl1545	lpc0898	lpa2161	lpw15031	llo1682	llb3727	+	+	+	legK1	STPK
lpg1484	lpp1440	lpl1544	lpc0899	lpa2162	lpw15041	–	–	−	−	−	–	Unknown
lpg1488	lpp1444	lpl1540	lpc0903*	lpa2168	lpw15081	–	–	−	−	−	lgt3/legc5	Coiled-coil
lpg1489	lpp1445	lpl1539	lpc0905	lpa2169	lpw15091	–	–	−	−	−	ravX	Unknown
lpg1491	lpp1447	–	–	–	–	–	–	−	−	−	lem9	Unknown
lpg1496	lpp1453	lpl1530	lpc0915	lpa2185	lpw15181	–	–	−	−	−	lem10	Unknown
lpg1551	lpp1508	lpl1475	lpc0972	lpa2253	–	–	–	−	−	−	ravY	Unknown
lpg1578	lpp4178	lpl4143	lpc1002	lpa2292	lpw16011	llo1503	llb0148	+	+	+	–	Unknown
lpg1588	lpp1546	lpl1437	lpc1013	lpa2305	lpw16131	–	–	−	−	−	legC6	Coiled–coil
lpg1598	lpp1556	lpl1427	lpc1025	lpa2317	lpw16231	–	–	−	−	−	lem11	Unknown
lpg1602	lpp1567	lpl1423/26*	lpc1028	lpa2318	lpw16241	–	–	−	−	−	legL2	LRR
lpg1621	lpp1591	lpl1402	lpc1048	lpa2346	lpw16461	llo1014	llb0702	+	+	+	ceg23	Unknown
lpg1625	lpp1595	lpl1398	lpc1052	lpa2350	lpw16511	llo0719	llb1016	+	+	+	lem23	Unknown
lpg1639	lpp1609	lpl1387	lpc1068	lpa2367	lpw16651	–	–	−	−	−	–	Unknown
lpg1642	lpp1612a/b	lpl1384	lpc1071	lpa2371	lpw16681	–	–	−	−	−	sidB	Putative hydrolase
lpg1654	lpp1625	–	lpc1084	lpa2390	–	llo0791	llb0935	+	+	+	–	Unknown
lpg1660	lpp1631	lpl1625	lpc1090	lpa2398	lpw16861	–	–	−	−	−	legL3	LRR
lpg1661	lpp1632	lpl1626	lpc1091	lpa2399	lpw16871	llo1691	llb3715	+	+	+	–	Putative N-acetyl transferase
lpg1666	lpp1637	lpl1631	lpc1096	lpa2408	lpw16921	–	–	−	−	−	–	Unknown
lpg1667	lpp1638	lpl1632	lpc1097	lpa2409	lpw16931	–	–	−	−	−	–	Unknown
lpg1670	lpp1642	lpl1635	lpc1101	lpa2413	lpw16971	–	–	−	−	−	–	Unknown
lpg1683	–	–	lpc1114	lpa2431	–	llo2508	llb2843	+	+	+	ravZ	Unknown
lpg1684	–	–	lpc1115	lpa2432	–	llo2267	llb3113	+	+	+	–	Unknown
lpg1685	–	–	lpc1116	lpa2433	–	llo3208	llb2147	+	+	+	–	Unknown
lpg1687	lpp1656	lpl1650	lpc1118	lpa2437	lpw17121	–	–	−	−	−	mavA	Unknown
lpg1689	lpp1658	lpl1652	lpc1120	lpa2439	lpw17141	llo1697	llb3708	+	+	+	–	Unknown
lpg1692	–	–	lpc1123	lpa2442	–	–	–	−	−	−	–	Unknown
lpg1701	lpp1666	lpl1660	lpc1130	lpa2455	lpw17231	–	–	−	−	−	ppeA/legC3	Coiled-coil
lpg1702	lpp1667	lpl1661	lpc1131	lpa2456	lpw17241	–	–	−	−	−	ppeB	Unknown
lpg1716	lpp1681	lpl1675	lpc1146	lpa2474	lpw17391	–	–	−	−	−	–	Unknown
lpg1717	lpp1682	–	–	–	lpw17401	–	–	−	−	−	–	Unknown
lpg1718	lpp1683	lpl1682	lpc1152	lpa2484	lpw17411	–	–	−	−	−	ankI/legAS4	Ankyrin
lpg1751	lpp1715	lpl1715	lpc1191	lpa2538	lpw17761	llo2314	llb3061	+	+	+	–	Unknown
lpg1752	lpp1716	lpl1716	lpc1192	lpa2539	lpw17771	llo2315	llb3060	+	+	+	–	Unknown
lpg1776	lpp1740	lpl1740	lpc1217	lpa2570	lpw18031	llo1437	llb0214*	+	+	+	–	Unknown
lpg1797	–	–	lpc1239	lpa2599	lpw32931	–	–	−	−	−	rvfA	Unknown
lpg1798	lpp1761	lpl1761	lpc1241	lpa2600	lpw18281	llo0991	llb0731	+	+	+	marB	Unknown
lpg1803	lpp1766	lpl1766	lpc1246	lpa2606	lpw18331	llo2611	llb2729	+	+	+	–	Unknown
lpg1836	lpp1799	lpl1800	lpc1280	lpa2652	lpw18691	–	–	−	−	−	ceg25	Unknown
lpg1851	lpp1818	lpl1817	lpc1296	lpa2675	lpw18871	llo1047	llb0666	+	+	+	lem14	Unknown
lpg1884	lpp1848	lpl1845	lpc1331	lpa2714	lpw19161	–	–	−	−	−	ylfB/legC2	Coiled-coil
lpg1888	lpp1855	lpl1850	lpc1336	lpa2723	lpw19211	–	–	−	−	−	–	Unknown
lpg1890	–	lpl1852	lpc1338	lpa2726	lpw19231	–	–	−	−	−	legLC8	LRR, coiled-coil
lpg1907	lpp1882	lpl1871	lpc1361	lpa2762	lpw19461	llo1240	llb0452	+	+	+	–	Unknown
lpg1924	lpp1899	lpl1888	lpc1378	lpa2783	lpw19631	–	–	−	−	−	–	Unknown
lpg1933	lpp1914	lpl1903	lpc1406	lpa2811	lpw19721	–	–	−	−	−	lem15	Unknown
lpg1947	lpp1930	lpl1917*	–	lpa2835	lpw19951	–	–	−	−	−	lem16	Spectrin domain
lpg1948	–	–	–	–	–	–	–	−	−	−	legLC4	LRR, coiled-coil
lpg1949	lpp1931	lpl1918	lpc1422	lpa2837	lpw19961	–	–	−	−	−	lem17	Unknown
lpg1950	lpp1932	lpl1919	lpc1423	lpa2838	lpw19971	llo1397	llb0259	+	+	+	ralF	Sec7 domain
lpg1953	lpp1935	lpl1922	lpc1426	lpa2842	lpw20041	–	–	−	−	−	legC4	Coiled-coil
lpg1958	lpp1940	–	–	–	–	–	–	−	−	−	legL5	LRR
lpg1959	lpp1941	–	–	lpa2857	lpw20101	–	–	−	−	−	–	Unknown
lpg1960	lpp1942	lpl1934*	lpc1437	lpa2859	lpw20111	llo0565	llb1288	+	+	+	lirA	Unknown
lpg1962	lpp1946	lpl1936	lpc1440	lpa2861	lpw20131	–	–	−	−	−	lirB	Rotamase
lpg1963	–	–	lpc1441/42	lpa2863	–	–	–	−	−	−	pieA/lirC	Unknown
lpg1964	–	–	–	–	–	–	–	−	−	−	pieB/lirD	Unknown
lpg1965	–	–	lpc1443/45	lpa2865	lpw20141	–	–	−	−	−	pieC/lirE	Unknown
lpg1966	lpp1947	–	lpc1446	lpa2867	lpw20151	–	–	−	−	−	pieD/lirF	Unknown
lpg1969	lpp1952	lpl1941	lpc1452	lpa2874	lpw20201	llo3131	llb2239	+	+	+	pieE	Unknown
lpg1972	lpp1955	lpl1950	lpc1459	lpa2884	lpw20291	–	–	−	−	−	pieF	Unknown
lpg1975	lpp1959	lpl1953	lpc1462	lpa2889(1)	lpw20351	–	–	−	−	−	–	Unknown
lpg1976	lpp1959	lpl1953	lpc1462	lpa2889(2)	lpw20351	–	–	−	−	−	pieG/legG1	Regulator of chromosome condensation
lpg1978	lpp1961	lpl1955	lpc1464	lpa2892	lpw20371	–	–	−	−	−	setA	Putative Glyosyltransferase
lpg1986	lpp1967	lpl1961	lpc1469	lpa2898	lpw20431	–	–	−	−	−	–	Unknown
lpg2050	lpp2033	lpl2028	lpc1536	lpa2992	lpw21141	–	–	−	−	−	–	Unknown
lpg2131	–	–	–	–	–	–	–	−	−	−	legA6	Unknown
lpg2137	lpp2076	lpl2066	lpc1586	lpa3060	lpw23101	–	–	−	−	−	legK2	STPK
lpg2144	lpp2082	lpl2072	lpc1593	lpa3071	lpw23181	–	–	−	−	−	ankB/legAU13/ceg27	Ankyrin, F-box
lpg2147	lpp2086	lpl2075	lpc1596	lpa3076	lpw23211	–	–	−	−	−	mavC	Unknown
lpg2148	lpp2087	lpl2076	lpc1597	lpa3077	lpw23221	–	–	−	−	−	–	Unknown
lpg2149	lpp2088	lpl2077	lpc1598	lpa3078	lpw23231	–	–	−	−	−	–	Unknown
lpg2153	lpp2092	lpl2081	lpc1602	lpa3083	lpw23271	–	–	−	−	−	sdeC	Unknown
lpg2154	lpp2093	lpl2082	lpc1603	lpa3086	lpw23281	llo3097	llb2278	+	+	+	sdeC	Unknown
lpg2155	lpp2094	lpl2083	lpc1604	lpa3087	lpw23291	llo3096	llb2279	+	+	+	sidJ	Unknown
lpg2156	lpp2095	lpl2084	lpc1605	lpa3088	lpw23301	llo3095	llb2280	+	+	+?	sdeB	Unknown
lpg2157	lpp2096	lpl2085	lpc1618	lpa3037	lpw23331	–	–	−	−	−	sdeC	Unknown
lpg2166	lpp2104	lpl2093	lpc1626	lpa3107	lpw23451	llo2398	llb2969	+	+	+	lem19	Unknown
lpg2160	lpp2099	lpl2088	lpc1621	lpa3100	lpw23361	llo2645	llb2690	+	+	+	–	Unknown
lpg2176	lpp2128	lpl2102	lpc1635	lpa3118	lpw23561	–	–	–	–	–	legS2	Sphingosine-1-phosphate lyase
lpg2199	lpp2149	lpl2123	lpc1663	lpa3157	lpw23811	–	–	–	–	–	cegC4	Unknown
lpg2200	lpp2150	lpl2124	lpc1664	lpa3158	lpw23821	–	–	–	–	–	cegC4	Unknown
lpg2215	lpp2166	lpl2140	lpc1680	lpa3179	lpw24011	–	–	–	–	–	legA2	Ankyrin
lpg2216	lpp2167	lpl2141	lpc1681	lpa3180	lpw24021	–	–	–	–	–	lem20	Unknown
lpg2222	lpp2174	lpl2147	lpc1689	lpa3191	lpw24081	llo1443	llb0208	+	+	+	lpnE	Putative beta-lactamase (SEL1 domain)
lpg2223	lpp2175	lpl2149*	lpc1691	lpa3196	lpw24091	–	–	–	–	–	–	Unknown
lpg2224	–	–	–	–	–	–	–	–	–	–	ppgA	Regulator of chromosome condensation
lpg2239	lpp2192	–	–	–	lpw24261	–	–	–	–	–	–	Unknown
lpg2248	lpp2202	lpl2174	lpc1717	lpa3237	lpw24371	–	–	–	–	–	lem21	Unknown
lpg2271	lpp2225	lpl2197	lpc1740	lpa3268	lpw24611	llo2530	llb2821	+	+	+	–	Unknown
lpg2298	lpp2246	lpl2217	lpc1763	lpa3296	lpw24841	llo1707	llb3696	+	+	+	ylfA/legC7	Coiled-coil
lpg2300	lpp2248	lpl2219	lpc1765	lpa3298	lpw24871	llo0584	llb1266	+	+	+	ankH/legA3, ankW	Ankyrin, NfkappaB inhibitor
lpg2311	lpp2259	lpl2230	lpc1776	lpa3312	lpw24981	–	–	−	−	−	ceg28	Unknown
lpg2322	lpp2270	lpl2242	lpc1789	lpa3328	lpw25121	llo0570	llb1282	+	+	+	ankK/legA5	Ankyrin
lpg2327	lpp2275	lpl2247	lpc1794	lpa3335	lpw25181	–	–	−	−	−	–	Unknown
lpg2328	lpp2276	lpl2248	lpc1795	lpa3336	lpw25191	–	–	−	−	−	lem22	Unknown
lpg2344	lpp2292	lpl2265	lpc1812	lpa3355	lpw25371	–	–	−	−	−	mavE	Unknown
lpg2351	lpp2300	lpl2273	lpc1820	lpa3367	lpw25461	llo2850	llb2466	+	+	+	mavF	Unknown
lpg2359	lpp2308	lpl2281	lpc1828	lpa3376	lpw25561	llo2856	llb2460	+	+	+	–	Unknown
lpg2370	–	–	–	–	–	–	–	−	−	−	–	HipA fragment
lpg2372	lpp3009	–	lpc3248	lpa4300	–	–	–	−	−	−	–	Unknown
lpg2382	lpp2444	lpl2300	lpc2108	lpa3446	lpw25841	llo1576	llb0071	+	+	+	–	Unknown
lpg2391	lpp2458	lpl2315	lpc2086	lpa3485	lpw26021	–	–	−	−	−	sdbC	Unknown
lpg2392	lpp2459	lpl2316	lpc2085	lpa3486	lpw26041	–	–	−	−	−	legL6	LRR
lpg2400	–	lpl2323	–	–	lpw26121	–	–	−	−	−	legL6	LRR
lpg2406	lpp2472	lpl2329	lpc2070	lpa3506	lpw26191	llo2172	llb3225	+	+	+	lem23	Unknown
lpg2407	lpp2474	–	lpc2069	lpa3507	–	–	–	−	−	−	–	Unknown
lpg2409	lpp2476	lpl2332	lpc2067	lpa3511	lpw26241	–	–	−	−	−	ceg29	Unknown
lpg2410	lpp2479	lpl2334	lpc2065	lpa3513	lpw26261	–	–	−	−	−	vpdA	Patatin domain
lpg2411	lpp2480	lpl2335	lpc2064	lpa3515	lpw26281	llo2227	llb3158	+	+	+	lem24	Unknown
–	lpp2486	–	–	–	–				−	−	–	F-box
lpg2416	–	lpl2339	lpc2057	lpa3527	lpw26351	–	–	−	−	−	legA1	Unknown
lpg2420	–	lpl2343	lpc2056	lpa3529	lpw26391	–	–	−	−	−	–	Unknown
lpg2422	lpp2487	lpl2345	lpc2055	lpa3530	lpw26401	llo1650	llb3763/64	+	+	+	lem25	Unknown
lpg2424	lpp2489	lpl2347	lpc2053	lpa3532	lpw26421	–	–	−	−	−	mavG	Unknown
lpg2425	lpp2491	lpl2348	lpc2051	lpa3537	lpw26431	–	–	−	−	−	mavH	Unknown
lpg2433	lpp2500	lpl2353	lpc2043	lpa3548	lpw26521	–	–	−	−	−	ceg30	Unknown
lpg2434	lpp2501	lpl2355	lpc2042	lpa3550	lpw26531	–	–	−	−	−	–	Unknown
lpg2443	lpp2510	lpl2363	lpc2033	lpa3562	–	–	–	−	−	−	–	Unknown
lpg2444	lpp2511	lpl2364	lpc2032	lpa3563	lpw26641	–	–	−	−	−	mavI	Unknown
lpg2452	lpp2517	lpl2370	lpc2026	lpa3574	lpw26701	–	–	−	−	−	ankF/legA14/ceg31	Ankyrin
lpg2456	lpp2522	lpl2375	lpc2020	lpa3583	lpw26751	llo0365	llb1493	+	+	+	ankD/legA15	Ankyrin
lpg2461	lpp2527	lpl2380	lpc2015	lpa3589	lpw26801	llo1991	llb3433	+	+	+	–	Unknown
lpg2464	–	lpl2384	–	–	lpw26851	–	–	−	−	−	sidM/drrA	Unknown
lpg2465	–	lpl2385	–	–	lpw26861	–	–	−	−	−	sidD	Unknown
lpg2490	lpp2555	lpl2411	lpc1987	lpa3628	lpw27131	–	–	−	−	−	lepB	Coiled-coil, Rab1 GAP
lpg2482	lpp2546	lpl2402	lpc1996	lpa3615	lpw27041	–	–	−	−	−	sdbB	Unknown
lpg2498	lpp2566	lpl2420	lpc1975	lpa3646	lpw27241	–	–	−	−	−	mavJ	Unknown
lpg2504	lpp2572	lpl2426	lpc1967	lpa3658	lpw27301	llo2525	llb2826	+	+	+	sidI/ceg32	Unknown
lpg2505	lpp2573	lpl2427	lpc1966	lpa3659	lpw27311	llo2526	llb2825	+	+	+	–	Unknown
lpg2508	lpp2576	lpl2430	lpc1962/63*	lpa3666	lpw27341	–	–	−	−	−	sdjA	Unknown
lpg2509	lpp2577	lpl2431	lpc1961	lpa3667	lpw27351	llo3097	llb2278	+	+	+	sdeD	Unknown
lpg2510	lpp2578	lpl2432	lpc1960	lpa3668	–	llo3098	llb2276	+	+	+	sdcA	Unknown
lpg2511	lpp2579	lpl2433	lpc1959	lpa3669	lpw27371	–	–	−	−	−	sidC	PI(4)P binding domain
lpg2523	–	–	–	–	lpw27501	–	–	−	−	−	lem26	Unknown
lpg2525	–	–	–	–	–	–	–	−	−	−	mavK	Unknown
lpg2526	lpp2591	lpl2446	lpc1946	lpa3687	lpw27521	–	–	−	−	−	mavL	Unknown
lpg2527	lpp2592	lpl2447	lpc1944	lpa3688	lpw27531	llo3335	llb2002	+	+	+	–	Unknown
lpg2529	lpp2594	lpl2449	lpc1942	lpa3692	lpw27551	llo2238	llb3146	+	+	+	lem27	Unknown
lpg2538	lpp2604	lpl2459	lpc1930	lpa3706	lpw27671	–	–	−	−	−	–	Unknown
lpg2539	lpp2605	lpl2460	lpc1929	lpa3707	lpw27681	llo1348	llb0317	+	+	+	–	Unknown
lpg2541	lpp2607	lpl2462	lpc1927	lpa3710	lpw27701	–	–	−	−	−	–	Unknown
lpg2546	lpp2615	–	lpc1919	lpa3727	lpw27791	–	–	−	−	−	–	Unknown
lpg2552	lpp2622	lpl2473	lpc1911	lpa3738	lpw27871	llo1062	llb0648	+	+	+	–	Unknown
lpg2555	lpp2625	lpl2480	lpc1908	lpa3743	lpw27901	llo2220	llb3170	+	+	+	–	Unknown
lpg2556	lpp2626	lpl2481	lpc1906	lpa3745	lpw27911	llo2218	llb3172	+	+	+	legK3	STPK
lpg2577	lpp2629	lpl2499	lpc0570	lpa3768	lpw28241	–	–	−	−	−	mavM	Unknown
lpg2584	lpp2637	lpl2507	lpc0561	lpa3779	lpw28321	–	–	−	−	−	sidF	Unknown
lpg2588	lpp2641	lpl2511	lpc0557	lpa3784	lpw28361	llo2622	llb2718	+	+	+	legS1	Unknown
lpg2591	lpp2644	lpl2514	lpc0551	lpa3790	lpw28391	llo0626	llb1219	+	+	+	ceg33	Unknown
lpg2603	lpp2656	lpl2526	lpc0539	lpa3807	lpw28521	–	–	−	−	−	lem28	Unknown
lpg2628	lpp2681	lpl2553	lpc0513	lpa3846	lpw28781	–	–	−	−	−	–	Unknown
lpg2637	lpp2690	lpl2562	lpc0503	lpa3859	lpw28871	–	–	−	−	−	–	Unknown
lpg2638	lpp2691	lpl2563	lpc0502	lpa3861	lpw28891	llo2645	llb2690	+	+	+	mavV	Unknown
lpg2692	lpp2746	lpl2619	lpc0444	lpa3929	lpw29461	–	–	−	−	−	–	Unknown
lpg2694	lpp2748	lpl2621	lpc0442	lpa3931	lpw29481	–	–	−	−	−	legD1	Phyhd1 protein
lpg2718	lpp2775	lpl2646	lpc0415	lpa3966	lpw29771	–	–	−	−	−	wipA	Unknown
lpg2720	lpp2777	lpl2648	lpc0413	lpa3968	lpw29791	–	–	−	−	−	legN	cAMP-binding protein
lpg2744	lpp2800	lpl2669	lpc0386	lpa4004	lpw30031	–	–	−	−	−	–	Unknown
lpg2745	lpp2801	lpl2670	lpc0385	lpa4005	lpw30041	llo0308	llb1553	+	+	+	–	Unknown
lpg2793	lpp2839	lpl2708	lpc3079	lpa4063	lpw30471	–	–	−	−	−	lepA	Effector protein A
lpg2804	lpp2850	lpl2719	lpc3090	lpa4076	lpw30591	llo0267	llb1598	+	+	+	lem29	Unknown
lpg2815	lpp2867	lpl2730	lpc3101	lpa4089	lpw30711	llo0254	llb1612	+	+	+	mavN	Unknown
lpg2826	–	lpl2741	lpc3113	lpa4104	lpw30831	–	–	−	−	−	ceg34	Unknown
lpg2828	lpp2882	lpl2743	lpc3115	lpa4109	lpw30851	llo0783	llb0944	+	+	+	–	Unknown
lpg2829	lpp2883/86*	–	–	–	lpw30861	–	–	−	−	−	sidH	Unknown
lpg2830	lpp2887	–	–	–	lpw30881	–	–	−	−	−	lubX/legU2	U-box motif
lpg2831	lpp2888	–	–	–	lpw30891	–	–	−	−	−	VipD	Patatin-like phopholipase
lpg2832	lpp2889	lpl2744	lpc3116	lpa4110	lpw30921	llo0214	llb1656	+	+	+	–	Putative hydrolase
lpg2844	lpp2903	lpl2756	lpc3128	lpa4133	–	–	–	−	−	−	–	Unknown
lpg2862	–	–	–	–	–	–	–	−	−	−	Lgt2/legC8	Coiled-coil
lpg2874	lpp2933	lpl2787	lpc3160	lpa4176	lpw31411	–	–	–	–	–	–	Unknown
lpg2879	lpp2938	lpl2792	lpc3165	lpa4186	lpw31471	llo0192	llb1681	+	+	+	–	Unknown
lpg2884	lpp2943	lpl2797	lpc3170	lpa4193	lpw31531	llo0197	llb1676	+	+	+	–	Unknown
lpg2885	lpp2944	lpl2798	lpc3171	–	lpw31541	–	–	−	−	−	–	Unknown
lpg2888	lpp2947	lpl2801	lpc3174	lpa4199	lpw31571	llo0200	llb1672	+	+	+	–	Unknown
lpg2912	lpp2980	lpl2830	lpc3214	lpa4255	lpw31931	–	–	−	−	−	–	Unknown
lpg2936	lpp3004	lpl2865	lpc3243	lpa4293	lpw32251	llo0081	llb1804	+	+	+	–	rRNA small subunit methyltransferase E
lpg2975	lpp3047	lpl2904	lpc3290	lpa4358	−?	llo3405	llb1930	+	+	+	–	Unknown
lpg2999	lpp3071	lpl2927	lpc3315	lpa4395	lpw32851	–	–	−	−	−	legP	Astacin protease
lpg3000	lpp3072	lpl2928	lpc3316	lpa4397	lpw32861	llo3444	llb1887	+	+	+	–	Unknown

List of substrates is based on Isberg et al. (2009), De Felipe et al. (2008), Ninio et al. (2009), Zhu et al. (2011); AT = ATCC33462; *pseudogene, +? or −? strains 130b, C-4E7 and 98072 are not a finished sequence and not manually curated. Thus absence of a substrate can also be due to gaps in the sequence; shaded in gray, substrates conserved in all L. pneumophila and L. longbeachae genomes.