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. 2011 Aug 1;174(7):816–827. doi: 10.1093/aje/kwr190

Table 2.

Odds Ratios and 95% Confidence Intervals for the Association of Nutrients Involved in One-Carbon Metabolism With Risk of Hodgkin Lymphoma, Boston, Massachusetts, Metropolitan Area and State of Connecticut, 1997–2000

Quartile of Intake Median Nutrient Intake in Controls
 No. of Cases No. of Controls Model 1a
 Model 2b
Men Women OR 95% CI OR 95% CI
Folate, μg/day
    Total
        Q1 230 203 131 159 1.00 Referent 1.00 Referent
        Q2 325 308 107 160 0.82 0.59, 1.16 0.89 0.63, 1.27
        Q3 458 557 122 161 0.94 0.67, 1.33 1.06 0.75, 1.51
        Q4 790 812 137 158 1.13 0.81, 1.57 1.23 0.87, 1.75
            Ptrend 0.20 0.10
    From food
        Q1 211 189 121 160 1.00 Referent 1.00 Referent
        Q2 279 253 128 159 1.09 0.78, 1.53 1.09 0.78, 1.55
        Q3 362 316 130 161 1.11 0.79, 1.54 1.20 0.84, 1.70
        Q4 459 436 118 158 1.02 0.72, 1.43 1.15 0.80, 1.64
            Ptrend 0.94 0.41
Vitamin B2, mg/day
    Total
        Q1 1.3 1.1 126 160 1.00 Referent 1.00 Referent
        Q2 1.7 1.6 101 160 0.78 0.55, 1.11 0.77 0.54, 1.11
        Q3 2.2 2.8 130 160 1.05 0.74, 1.47 1.08 0.76, 1.54
        Q4 4.0 4.3 140 158 1.18 0.85, 1.65 1.17 0.83, 1.65
            Ptrend 0.08 0.08
    From food
        Q1 1.2 1.0 114 160 1.00 Referent 1.00 Referent
        Q2 1.5 1.3 121 159 1.07 0.76, 1.50 0.98 0.69, 1.39
        Q3 1.8 1.6 143 162 1.23 0.88, 1.72 1.17 0.82, 1.65
        Q4 2.3 2.1 119 157 1.07 0.76, 1.50 0.98 0.69, 1.41
            Ptrend 0.70 0.96
Vitamin B6, mg/day
    Total
        Q1 1.5 1.3 125 159 1.00 Referent 1.00 Referent
        Q2 1.9 1.9 116 159 0.97 0.69, 1.37 1.04 0.73, 1.49
        Q3 2.6 3.4 110 162 0.91 0.64, 1.29 1.03 0.72, 1.49
        Q4 5.3 6.2 146 158 1.29 0.92, 1.80 1.38 0.98, 1.97
            Ptrend 0.07 0.05
    From food
        Q1 1.4 1.2 125 160 1.00 Referent 1.00 Referent
        Q2 1.7 1.5 119 159 0.96 0.69, 1.34 0.96 0.78, 1.36
        Q3 2.0 1.8 130 160 1.05 0.75, 1.47 1.18 0.83, 1.67
        Q4 2.5 2.2 123 159 1.05 0.75, 1.48 1.13 0.79, 1.61
            Ptrend 0.70 0.38
Vitamin B12, μg/day
    Total
        Q1 3.3 2.7 107 161 1.00 Referent 1.00 Referent
        Q2 4.7 4.6 127 158 1.22 0.86, 1.72 1.26 0.88, 1.79
        Q3 7.7 8.9 124 162 1.21 0.86, 1.71 1.18 0.82, 1.68
        Q4 17.4 16.1 139 157 1.42 1.00, 2.00 1.52 1.06, 2.17
            Ptrend 0.11 0.05
    From food
        Q1 2.9 2.5 106 161 1.00 Referent 1.00 Referent
        Q2 4.0 3.4 119 157 1.17 0.83, 1.65 1.18 0.83, 1.69
        Q3 5.4 4.5 148 163 1.39 0.99, 1.95 1.37 0.97, 1.94
        Q4 8.5 6.8 124 157 1.25 0.88, 1.77 1.29 0.90, 1.84
            Ptrend 0.22 0.17
Methionine, g/day
    From food
        Q1 1.3 1.1 130 160 1.00 Referent 1.00 Referent
        Q2 1.6 1.5 139 159 1.07 0.77, 1.49 1.15 0.82, 1.61
        Q3 1.9 1.8 119 161 0.87 0.62, 1.22 0.97 0.68, 1.37
        Q4 2.3 2.2 109 158 0.85 0.60, 1.19 0.94 0.66, 1.34
            Ptrend 0.23 0.57
Current multivitamin usec
    No 266 368 1.00 Referent 1.00 Referent
    Yes 224 264 1.21 0.95, 1.55 1.25 0.97, 1.61
            Ptrend 0.12 0.08

Abbreviations: CI, confidence interval; OR, odds ratio; Q, quartile.

a

Adjusted for age (5-year age groups), sex (male, female), state of residence (Connecticut, Massachusetts), and total energy intake (continuous).

b

Additionally adjusted for race/ethnicity (white, nonwhite), smoking history (ever, never), regular aspirin use (yes, no, missing), regular acetaminophen use (yes, no, missing), education (less than high school, high school, college, advanced degree), nursery school attendance for more than 1 year (yes, no, missing/don't know), and alcohol intake (nondrinker, drinker).

c

Excludes 13 participants missing current multivitamin use.