Table 3.

Odds Ratios and 95% Confidence Intervals for the Association of Nutrients Involved in One-Carbon Metabolism With Risk of EBV-positive or -negative Hodgkin Lymphoma, Boston, Massachusetts, Metropolitan Area and State of Connecticut, 1997–2000

Quartile of Intake	No. of Controls	EBV-positive Diseasea			EBV-negative Diseasea
		No. of Cases	OR	95% CI	No. of Cases	OR	95% CI
Folate, μg/day
Total
Q1	159	20	1.00	Referent	73	1.00	Referent
Q2	160	19	1.08	0.54, 2.14	59	0.82	0.54, 1.25
Q3	161	16	0.93	0.45, 1.92	80	1.20	0.80, 1.79
Q4	158	26	1.61	0.83, 3.11	74	1.21	0.80, 1.83
Ptrend			0.16			0.10
From food
Q1	160	17	1.00	Referent	64	1.00	Referent
Q2	159	23	1.41	0.72, 2.79	75	1.24	0.83, 1.86
Q3	161	22	1.57	0.78, 3.17	81	1.35	0.90, 2.02
Q4	158	19	1.32	0.64, 2.70	66	1.16	0.76, 1.77
Ptrend			0.44			0.56
Vitamin B2, mg/day
Total
Q1	160	17	1.00	Referent	72	1.00	Referent
Q2	160	17	1.05	0.50, 2.19	53	0.73	0.47, 1.12
Q3	160	19	1.19	0.57, 2.48	86	1.31	0.87, 1.97
Q4	158	28	1.94	0.99, 3.80	75	1.19	0.79, 1.79
Ptrend			0.04			0.07
From food
Q1	160	17	1.00	Referent	67	1.00	Referent
Q2	159	20	1.25	0.62, 2.52	73	1.09	0.72, 1.63
Q3	162	17	1.04	0.51, 2.16	80	1.17	0.78, 1.74
Q4	157	27	1.74	0.90, 3.40	66	1.05	0.69, 1.58
Ptrend			0.10			0.89
Vitamin B6, mg/day
Total
Q1	159	23	1.00	Referent	62	1.00	Referent
Q2	159	17	0.78	0.39, 1.56	74	1.31	0.86, 2.00
Q3	162	15	0.73	0.35, 1.51	70	1.29	0.84, 1.99
Q4	158	26	1.33	0.70, 2.53	80	1.62	1.06, 2.47
Ptrend			0.25			0.03
From food
Q1	160	20	1.00	Referent	67	1.00	Referent
Q2	159	19	1.05	0.53, 2.08	78	1.24	0.83, 1.86
Q3	160	18	1.03	0.52, 2.07	79	1.26	0.84, 1.89
Q4	159	24	1.45	0.74, 2.83	62	1.11	0.72, 1.69
Ptrend			0.28			0.75
Vitamin B12, μg/day
Total
Q1	161	18	1.00	Referent	57	1.00	Referent
Q2	158	19	1.13	0.56, 2.28	71	1.33	0.87, 2.04
Q3	162	24	1.41	0.72, 2.78	77	1.48	0.97, 2.26
Q4	157	20	1.20	0.59, 2.44	81	1.75	1.15, 2.68
Ptrend			0.86			0.02
From food
Q1	161	18	1.00	Referent	60	1.00	Referent
Q2	157	21	1.27	0.64, 2.53	70	1.22	0.81, 1.86
Q3	163	20	1.24	0.62, 2.48	84	1.42	0.95, 2.14
Q4	157	22	1.35	0.68, 2.67	72	1.37	0.90, 2.09
Ptrend			0.45			0.15
Methionine, g/day
From food
Q1	160	25	1.00	Referent	66	1.00	Referent
Q2	159	23	0.98	0.52, 1.84	77	1.20	0.80, 1.81
Q3	161	21	0.96	0.51, 1.83	72	1.08	0.71, 1.63
Q4	158	12	0.53	0.25, 1.12	71	1.13	0.75, 1.71
Ptrend			0.12			0.66
Current multivitamin useb
No	368	49	1.00	Referent	144	1.00	Referent
Yes	264	30	0.98	0.59, 1.62	139	1.46	1.09, 1.96
Ptrend			0.92			0.01

Abbreviations: CI, confidence interval; EBV, Epstein-Barr virus; OR, odds ratio; Q, quartile.

^aAdjusted for age (5-year age groups), sex (male, female), state of residence (Connecticut, Massachusetts), total energy intake (continuous), smoking history (ever, never), and education (less than high school, high school, college, advanced degree).

^bExcludes 13 participants missing current multivitamin use.