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Cross-species protection following a 2-dose vaccination regime using a dual recombinant vesicular stomatitis virus (rVSV) vector expressing Sudan ebolavirus antigens. Guinea pigs (n = 6) were vaccinated twice (day 0, day 21) with the indicated rVSV vaccine vectors and challenged 42 days after the initial immunization with 1000 median lethal dose (LD50) of guinea pig–adapted Zaire ebolavirus. Animals were monitored for weight loss (A) and survival (B).
