Table 3.
Multivariable analysis of factors associated with hypertriglyceridemia in HIV-infected children on HAART
| Hypertriglyceridemia |
Adjusted |
||||
|---|---|---|---|---|---|
| Yes (N = 140) | No (N = 337) | p-valuea | AORb | 95% CI | |
| HAART regimen | |||||
| NNRTI-containing | 17 (15.2%) | 95 (84.8%) | <0.001 | Reference | |
| PI-containing | 107 (34.4%) | 204 (65.6%) | 3.5 | 1.9–6.4 | |
| PI + NNRTI-containing | 16 (29.6%) | 38 (70.4%) | 2.1 | 0.9–4.8 | |
| BMI category (Z-score percentile) | |||||
| Normal (5th to 84th) | 98 (27.6%) | 257 (72.4%) | 0.10 | Reference | |
| Underweight (<5th) | 19 (43.2%) | 25 (56.8%) | 2.1 | 1.1–4.2 | |
| Overweight (≥85th) | 21 (29.2%) | 51 (70.8%) | 1.2 | 0.7–2.2 | |
| Missing | 2 | 4 | |||
| Age at time of initiating current HAART regimen, years | |||||
| <2 | 26 (31.0) | 58 (69.0) | 0.03 | 0.4 | 0.2–1.0 |
| 2–5 | 53 (24.0) | 168 (76.0) | 0.3 | 0.1–0.7 | |
| 6–11 | 44 (32.6) | 91 (67.4) | 0.5 | 0.2–1.1 | |
| ≥12 | 17 (45.9) | 20 (54.1) | Reference | ||
| Previous HAART regimen | |||||
| Yes | 72 (35.1) | 133 (64.9) | 0.02 | 1.6 | 1.0–2.5 |
| No | 68 (25.0) | 204 (75.0) | |||
ap-values calculated from chi square for bivariate analysis.
bAll variables in Table 1 were considered at bivariate analysis, six variables (HAART regimen, age at lab test, BMI, country of residence, previous HAART regimen, and age at the time of initiating the current HAART regimen) met criteria for the multivariable model (p ≤ 0.2 in bivariate analysis). Only the variables shown in this table remained in the final model.