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Subtypes of CD4+ Treg and supposed mechanism of action
| Term | Markers | Origin | Mechanism of action |
|---|---|---|---|
| Natural Treg | CD25 FOXP3 | Thymus | Cell–cell contact and suppressive cytokines |
| CTLA-4 GITR | |||
| Adaptive Treg | CD25 FOXP3 | Induced in the periphery | Cell–cell contact and suppressive cytokines |
| CTLA-4 GITR | |||
| Tr1 | – | Induced in the periphery | IL-10 production |
| Th3 | – | Induced in the periphery | TGF-β production |
