Table 1.
Term | Markers | Origin | Mechanism of action |
---|---|---|---|
Natural Treg | CD25 FOXP3 | Thymus | Cell–cell contact and suppressive cytokines |
CTLA-4 GITR | |||
Adaptive Treg | CD25 FOXP3 | Induced in the periphery | Cell–cell contact and suppressive cytokines |
CTLA-4 GITR | |||
Tr1 | – | Induced in the periphery | IL-10 production |
Th3 | – | Induced in the periphery | TGF-β production |