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. 2011 Aug 27;55(3):e26. doi: 10.4081/ejh.2011.e26

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©Copyright M. Malatesta et al., 2011

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Young (a–c) and senescing (d–f) DM2 myoblasts. (a) The myoblast shows an elongated shape and one ovoid nucleus with a reticular nucleolus (Nu) and scarce heterochromatin. In the cytoplasm, rough endoplasmic reticulum (arrows), a Golgi complex (g) and many vacuoles (v) are visible. Scale bar: 2 µm. (b,c) Cytoplasmic details showing well developed rough endoplasmic reticulum (arrows), Golgi complexes (g), free ribosomes, elongated mitochondria (m), and many vacuoles with heterogeneous content (v). Cytoplasmic electron lucent areas (stars) sometimes occur. Scale bars: 1 µm. (d) The myoblast shows a very elongated shape and one irregularly shaped nucleus with evident heterochromatin. In the cytoplasm, well developed Golgi complexes (g), and vacuoles (v) are visible. Scale bar: 2 µm. (e) Large cytoplasmic regions are filled with heterogeneous vacuoles (v) or appear as electron lucent areas (stars). Scale bar: 2 µm. (f) Cytoplasmic detail showing rough endoplasmic reticulum (arrow), Golgi complexes (g), glycogen clusters (star) and numerous vacuoles (v). Scale bar: 1 µm.