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Effect of Raf loss on survival, MAPK activation and proliferation. (A,B) Survival is extended by homozygous loss of B-Raf (A) or C-Raf (B) in the context of K-RasG12D. (C) Reduced MAPK activation in BBK tumors at endpoint. (D) Reduced proliferation of BBK tumors at 12 weeks post Ad-Cre infection. (E, F) Evaluation of recombination of floxed Raf alleles by genotyping PCR of laser capture micro-dissected tumors.
