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Deletion of ULS1 suppresses DNA damage sensitivity of sgs1Δ but not rmi1Δ–top3Δ and shows synergistic effect with mus81Δ for decreased resistance to DNA damaging agents. Mutants were transformed with the centromeric plasmid bearing the wild-type ULS1 gene (pGURA3_ULS1) or the mutated version uls1-D1108A,E1109A (pGURA3_uls1-hd) encoding the catalytic inactive Uls1 (uls1-hd). Growth test in the presence of HU, MMS and CPT was performed as in Figure 1.
