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. 2011 Aug 24;39(20):e138. doi: 10.1093/nar/gkr616

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — (A) Graphical representation of the exhaustive design strategy. Starting from a library of composable genetic regulatory elements (mathematical models provided in SBML format in the Supplementary File sbml.zip), we constructed all possible circuits up to three genes for simulation. (B) Dynamical spectrum of the library by exhaustive exploration (functional diversity). We represent the percentage of circuits that behave as oscillators, amplitude filters, memories and logic gates (designability). To differentiate between two states of a circuit, we imposed at least one order of magnitude in concentration.